SLITRK5 explained

SLIT and NTRK-like protein 5 is a protein that in humans is encoded by the SLITRK5 gene.^{[1] [2] [3]}

Function

Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003).[supplied by OMIM]

Further reading

• Amanchy R, Kalume DE, Iwahori A, Zhong J, Pandey A . Phosphoproteome analysis of HeLa cells using stable isotope labeling with amino acids in cell culture (SILAC) . Journal of Proteome Research . 4 . 5 . 1661–71 . 2006 . 16212419 . 10.1021/pr050134h .
• Aruga J, Mikoshiba K . Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth . Molecular and Cellular Neurosciences . 24 . 1 . 117–29 . September 2003 . 14550773 . 10.1016/S1044-7431(03)00129-5 . 25473221 .

Notes and References

1. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Research . 5 . 6 . 355–64 . December 1998 . 10048485 . 10.1093/dnares/5.6.355 . free .
2. Aruga J, Yokota N, Mikoshiba K . Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue . Gene . 315 . 87–94 . October 2003 . 14557068 . 10.1016/S0378-1119(03)00715-7 .
3. Web site: Entrez Gene: SLITRK5 SLIT and NTRK-like family, member 5.