SLITRK2 explained
SLIT and NTRK-like protein 2 is a protein that in humans is encoded by the SLITRK2 gene.[1] [2] [3]
Function
Members of the SLITRK family, such as SLITRK2, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK2, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity.[2]
Further reading
- Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . September 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
Notes and References
- Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O . Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Research . 8 . 2 . 85–95 . April 2001 . 11347906 . 10.1093/dnares/8.2.85 . free .
- Aruga J, Yokota N, Mikoshiba K . Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue . Gene . 315 . 87–94 . October 2003 . 14557068 . 10.1016/S0378-1119(03)00715-7 .
- Web site: Entrez Gene: SLITRK2 SLIT and NTRK-like family, member 2.
