SLIT2 explained

Slit homolog 2 protein is a protein that in humans is encoded by the SLIT2 gene.^{[1] [2] [3]}

Interactions

SLIT2 has been shown to interact with Glypican 1.^[4]

Further reading

• Wong K . Park HT . Wu JY . Rao Y . Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes. . Curr. Opin. Genet. Dev. . 12 . 5 . 583–91 . 2003 . 12200164 . 10.1016/S0959-437X(02)00343-X .
• Zhao XC . Zhang LM . Li Q . Tong DY . Fan LC . An P . Wu XY . Chen WM . Zhao P . Wang J. . Isoflurane post-conditioning protects primary cultures of cortical neurons against oxygen and glucose deprivation injury via upregulation of Slit2/Robo1. . Brain Res. . 1537 . 283–9 . 2013 . 23994690 . 10.1016/j.brainres.2013.08.036 . 3820100.
• Wang KH, Brose K, Arnott D, etal . Biochemical purification of a mammalian slit protein as a positive regulator of sensory axon elongation and branching. . Cell . 96 . 6 . 771–84 . 1999 . 10102266 . 10.1016/S0092-8674(00)80588-7 . 16810644 . free .
• Brose K, Bland KS, Wang KH, etal . Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. . Cell . 96 . 6 . 795–806 . 1999 . 10102268 . 10.1016/S0092-8674(00)80590-5 . 16301178 . free .
• Li HS, Chen JH, Wu W, etal . Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons. . Cell . 96 . 6 . 807–18 . 1999 . 10102269 . 10.1016/S0092-8674(00)80591-7 . free .
• Nguyen Ba-Charvet KT, Brose K, Marillat V, etal . Slit2-Mediated chemorepulsion and collapse of developing forebrain axons. . Neuron . 22 . 3 . 463–73 . 1999 . 10197527 . 10.1016/S0896-6273(00)80702-3 . 18663762 . free .
• Holmes GP, Negus K, Burridge L, etal . Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis. . Mech. Dev. . 79 . 1–2 . 57–72 . 1999 . 10349621 . 10.1016/S0925-4773(98)00174-9 . 6057216 . free .
• Liang Y, Annan RS, Carr SA, etal . Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain. . J. Biol. Chem. . 274 . 25 . 17885–92 . 1999 . 10364234 . 10.1074/jbc.274.25.17885 . free .
• Wu W, Wong K, Chen J, etal . Directional guidance of neuronal migration in the olfactory system by the protein Slit. . Nature . 400 . 6742 . 331–6 . 1999 . 10432110 . 10.1038/22477 . 2041931 . 1999Natur.400..331W .
• Georgas K, Burridge L, Smith K, etal . Assignment of the human slit homologue SLIT2 to human chromosome band 4p15.2. . Cytogenet. Cell Genet. . 86 . 3–4 . 246–7 . 2000 . 10575218 . 10.1159/000015351 . 6028258 .
• Niclou SP . Jia L . Raper JA . Slit2 is a repellent for retinal ganglion cell axons. . J. Neurosci. . 20 . 13 . 4962–74 . 2000 . 10864954 . 10.1523/JNEUROSCI.20-13-04962.2000. 6772294 .
• Zou Y . Stoeckli E . Chen H . Tessier-Lavigne M . Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord. . Cell . 102 . 3 . 363–75 . 2000 . 10975526 . 10.1016/S0092-8674(00)00041-6 . 14174593 . 2020-09-11 . 2018-11-01 . https://web.archive.org/web/20181101080448/https://www.zora.uzh.ch/id/eprint/248/1/Zou_00.pdf . dead .
• Chen JH, Wen L, Dupuis S, etal . The N-terminal leucine-rich regions in Slit are sufficient to repel olfactory bulb axons and subventricular zone neurons. . J. Neurosci. . 21 . 5 . 1548–56 . 2001 . 11222645 . 10.1523/JNEUROSCI.21-05-01548.2001. 6762944 . free .
• Wu JY, Feng L, Park HT, etal . The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors. . Nature . 410 . 6831 . 948–52 . 2001 . 11309622 . 10.1038/35073616 . 2072862 . 2001Natur.410..948W .
• Ronca F . Andersen JS . Paech V . Margolis RU . Characterization of Slit protein interactions with glypican-1. . J. Biol. Chem. . 276 . 31 . 29141–7 . 2001 . 11375980 . 10.1074/jbc.M100240200 . free .
• Nguyen Ba-Charvet KT, Brose K, Ma L, etal . Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance. . J. Neurosci. . 21 . 12 . 4281–9 . 2001 . 11404413 . 10.1523/JNEUROSCI.21-12-04281.2001. 6762758 . free .
• Little M, Rumballe B, Georgas K, etal . Conserved modularity and potential for alternate splicing in mouse and human Slit genes. . Int. J. Dev. Biol. . 46 . 4 . 385–91 . 2003 . 12141424 .
• Dallol A, Da Silva NF, Viacava P, etal . SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers. . Cancer Res. . 62 . 20 . 5874–80 . 2002 . 12384551 .

Notes and References

1. Itoh A . Miyabayashi T . Ohno M . Sakano S . Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system . Brain Res Mol Brain Res . 62 . 2 . 175–86 . February 1999 . 9813312 . 10.1016/S0169-328X(98)00224-1 .
2. Book: Chedotal A . Slits and Their Receptors . Axon Growth and Guidance . Advances in Experimental Medicine and Biology . 621 . 65–80 . February 2008 . 18269211 . 10.1007/978-0-387-76715-4_5 . 978-0-387-76714-7 .
3. Web site: Entrez Gene: SLIT2 slit homolog 2 (Drosophila).
4. Ronca . F . Andersen J S . Paech V . Margolis R U . August 2001 . Characterization of Slit protein interactions with glypican-1 . J. Biol. Chem. . 276 . 31 . 29141–7 . United States. 0021-9258. 11375980 . 10.1074/jbc.M100240200 . free .