SLFN5 explained

Schlafen family member 5 is a protein that in humans is encoded by the SLFN5 gene.^[1]

Katsoulidis E, Mavrommatis E, Woodard J, Shields MA, Sassano A, Carayol N, Sawicki KT, Munshi HG, Platanias LC . Role of interferon (IFN)-inducible Schlafen-5 in regulation of anchorage-independent growth and invasion of malignant melanoma cells . J. Biol. Chem. . 285 . 51 . 40333–41 . December 2010 . 20956525 . 3001013 . 10.1074/jbc.M110.151076 . free .
Sassano A, Mavrommatis E, Arslan AD, Kroczynska B, Beauchamp EM, Khuon S, Chew TL, Green KJ, Munshi HG, Verma AK, Platanias LC . Human Schlafen 5 (SLFN5) Is a Regulator of Motility and Invasiveness of Renal Cell Carcinoma Cells . Mol. Cell. Biol. . 35 . 15 . 2684–98 . August 2015 . 26012550 . 4524119 . 10.1128/MCB.00019-15 .
Companioni Nápoles O, Tsao AC, Sanz-Anquela JM, Sala N, Bonet C, Pardo ML, Ding L, Simo O, Saqui-Salces M, Blanco VP, Gonzalez CA, Merchant JL . SCHLAFEN 5 expression correlates with intestinal metaplasia that progresses to gastric cancer . J. Gastroenterol. . 52 . 1 . 39–49 . January 2017 . 27032393 . 5045746 . 10.1007/s00535-016-1202-4 .
Arslan AD, Sassano A, Saleiro D, Lisowski P, Kosciuczuk EM, Fischietti M, Eckerdt F, Fish EN, Platanias LC . Human SLFN5 is a transcriptional co-repressor of STAT1-mediated interferon responses and promotes the malignant phenotype in glioblastoma . Oncogene . 36 . 43 . 6006–6019 . October 2017 . 28671669 . 5821504 . 10.1038/onc.2017.205 .

Notes and References