SLFN14 explained

Schlafen family member 14 is a protein that in humans is encoded by the SLFN14 gene.^[1]

Function

The protein encoded by this gene plays an important role in platelet formation and function. Defects in this gene are a cause of thrombocytopenia with excessive bleeding. [provided by RefSeq, Jul 2016].

Further reading

• Fletcher SJ, Johnson B, Lowe GC, Bem D, Drake S, Lordkipanidzé M, Guiú IS, Dawood B, Rivera J, Simpson MA, Daly ME, Motwani J, Collins PW, Watson SP, Morgan NV . SLFN14 mutations underlie thrombocytopenia with excessive bleeding and platelet secretion defects . J. Clin. Invest. . 125 . 9 . 3600–5 . September 2015 . 26280575 . 4588283 . 10.1172/JCI80347 .
• Marconi C, Di Buduo CA, Barozzi S, Palombo F, Pardini S, Zaninetti C, Pippucci T, Noris P, Balduini A, Seri M, Pecci A . SLFN14-related thrombocytopenia: identification within a large series of patients with inherited thrombocytopenia . Thromb. Haemost. . 115 . 5 . 1076–9 . May 2016 . 26769223 . 10.1160/TH15-11-0884 .
• Seong RK, Seo SW, Kim JA, Fletcher SJ, Morgan NV, Kumar M, Choi YK, Shin OS . Schlafen 14 (SLFN14) is a novel antiviral factor involved in the control of viral replication . Immunobiology . 222 . 11 . 979–988 . November 2017 . 28734654 . 5990420 . 10.1016/j.imbio.2017.07.002 .
• Fletcher SJ, Pisareva VP, Khan AO, Tcherepanov A, Morgan NV, Pisarev AV . Role of the novel endoribonuclease SLFN14 and its disease-causing mutations in ribosomal degradation . RNA . 24 . 7 . 939–949 . July 2018 . 29678925 . 6004054 . 10.1261/rna.066415.118 .

Notes and References

1. Web site: Entrez Gene: Schlafen family member 14. 2020-04-11.