Solute carrier organic anion transporter family member 2A1 explained

Solute carrier organic anion transporter family member 2A1, also known as the prostaglandin transporter (PGT), is a protein that in humans is encoded by the SLCO2A1 gene.^[1]

This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning organic anion-transporting polypeptide superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues.^[1]

Clinical relevance

Mutations in this gene have been shown to cause primary hypertrophic osteoarthropathy,^[2] specific form of chronic enteropathy.

Further reading

• Hagenbuch B, Meier PJ . Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties . Pflügers Archiv . 447 . 5 . 653–65 . February 2004 . 14579113 . 10.1007/s00424-003-1168-y . 21837213 .
• Huang CS, Huang MJ, Lin MS, Yang SS, Teng HC, Tang KS . Genetic factors related to unconjugated hyperbilirubinemia amongst adults . Pharmacogenetics and Genomics . 15 . 1 . 43–50 . January 2005 . 15864125 . 10.1097/01213011-200501000-00007 . 24247125 .
• Kang J, Chapdelaine P, Laberge PY, Fortier MA . Functional characterization of prostaglandin transporter and terminal prostaglandin synthases during decidualization of human endometrial stromal cells . Human Reproduction . 21 . 3 . 592–9 . March 2006 . 16339169 . 10.1093/humrep/dei400 . 6008841 . free .
• Choi K, Zhuang H, Crain B, Doré S . Expression and localization of prostaglandin transporter in Alzheimer disease brains and age-matched controls . Journal of Neuroimmunology . 195 . 1–2 . 81–7 . March 2008 . 18353443 . 2365511 . 10.1016/j.jneuroim.2008.01.014 .
• Holla VR, Backlund MG, Yang P, Newman RA, DuBois RN . Regulation of prostaglandin transporters in colorectal neoplasia . Cancer Prevention Research . 1 . 2 . 93–9 . July 2008 . 19138942 . 10.1158/1940-6207.CAPR-07-0009 . free .
• Chi Y, Schuster VL . The prostaglandin transporter PGT transports PGH(2) . Biochemical and Biophysical Research Communications . 395 . 2 . 168–72 . April 2010 . 20346915 . 10.1016/j.bbrc.2010.03.108 . 4410840 .
• Breuiller-Fouché M, Leroy MJ, Dubois O, Reinaud P, Chissey A, Qi H, Germain G, Fortier MA, Charpigny G . Differential expression of the enzymatic system controlling synthesis, metabolism, and transport of PGF2 alpha in human fetal membranes . Biology of Reproduction . 83 . 1 . 155–62 . July 2010 . 20357271 . 10.1095/biolreprod.109.080390 . free .
• Lu R, Kanai N, Bao Y, Schuster VL . Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT) . The Journal of Clinical Investigation . 98 . 5 . 1142–9 . September 1996 . 8787677 . 507536 . 10.1172/JCI118897 .
• Lu R, Schuster VL . Molecular cloning of the gene for the human prostaglandin transporter hPGT: gene organization, promoter activity, and chromosomal localization . Biochemical and Biophysical Research Communications . 246 . 3 . 805–12 . May 1998 . 9618293 . 10.1006/bbrc.1998.8715 .
• Topper JN, Cai J, Stavrakis G, Anderson KR, Woolf EA, Sampson BA, Schoen FJ, Falb D, Gimbrone MA . Human prostaglandin transporter gene (hPGT) is regulated by fluid mechanical stimuli in cultured endothelial cells and expressed in vascular endothelium in vivo . Circulation . 98 . 22 . 2396–403 . December 1998 . 9832484 . 10.1161/01.CIR.98.22.2396 . free .

Notes and References

1. Web site: Entrez Gene: Solute carrier organic anion transporter family, member 2A1. 2011-12-30 .
2. Zhang Z, Xia W, He J, Zhang Z, Ke Y, Yue H, Wang C, Zhang H, Gu J, Hu W, Fu W, Hu Y, Li M, Liu Y . Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy . American Journal of Human Genetics . 90 . 1 . 125–32 . January 2012 . 22197487 . 10.1016/j.ajhg.2011.11.019 . 3257902 .