Solute carrier organic anion transporter family member 1A2 explained

Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene.^{[1] [2]}

This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternate splicing of this gene results in three transcript variants encoding two different isoforms.

See also

• Solute carrier family

Further reading

• Meier PJ, Eckhardt U, Schroeder A, etal . Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver . Hepatology . 26 . 6 . 1667–77 . 1998 . 9398014 . 10.1002/hep.510260641 . 20039812 .
• Kullak-Ublick GA, Hagenbuch B, Stieger B, etal . Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver . Gastroenterology . 109 . 4 . 1274–82 . 1995 . 7557095 . 10.1016/0016-5085(95)90588-X .
• Kullak-Ublick GA, Beuers U, Fahney C, etal . Identification and functional characterization of the promoter region of the human organic anion transporting polypeptide gene . Hepatology . 26 . 4 . 991–7 . 1997 . 9328325 . 10.1002/hep.510260429 . 43606355 .
• Kullak-Ublick GA, Fisch T, Oswald M, etal . Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain . FEBS Lett. . 424 . 3 . 173–6 . 1998 . 9539145 . 10.1016/S0014-5793(98)00168-9 . 21231745 . free .
• König J, Cui Y, Nies AT, Keppler D . Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide . J. Biol. Chem. . 275 . 30 . 23161–8 . 2000 . 10779507 . 10.1074/jbc.M001448200 . free .
• Tamai I, Nezu J, Uchino H, etal . Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family . Biochem. Biophys. Res. Commun. . 273 . 1 . 251–60 . 2000 . 10873595 . 10.1006/bbrc.2000.2922 .
• Speek M . Antisense Promoter of Human L1 Retrotransposon Drives Transcription of Adjacent Cellular Genes . Mol. Cell. Biol. . 21 . 6 . 1973–85 . 2001 . 11238933 . 10.1128/MCB.21.6.1973-1985.2001 . 86790 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Lee W, Glaeser H, Smith LH, etal . Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry . J. Biol. Chem. . 280 . 10 . 9610–7 . 2005 . 15632119 . 10.1074/jbc.M411092200 . free .
• Su Y, Zhang X, Sinko PJ . Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells . Mol. Pharm. . 1 . 1 . 49–56 . 2005 . 15832500 . 10.1021/mp0340136 .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .

Notes and References

1. Kullak-Ublick GA, Beuers U, Meier PJ, Domdey H, Paumgartner G . Assignment of the human organic anion transporting polypeptide (OATP) gene to chromosome 12p12 by fluorescence in situ hybridization . J Hepatol . 25 . 6 . 985–7 . Apr 1997 . 9007731 . 10.1016/S0168-8278(96)80307-2 .
2. Web site: Entrez Gene: SLCO1A2 solute carrier organic anion transporter family, member 1A2.