SLC9B2 explained

Solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 is a protein that in humans is encoded by the SLC9B2 gene.^[1]

Function

Sodium–hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux.^[2]

Further reading

• Kondapalli KC, Kallay LM, Muszelik M, Rao R . Unconventional chemiosmotic coupling of NHA2, a mammalian Na+/H+ antiporter, to a plasma membrane H+ gradient . The Journal of Biological Chemistry . 287 . 43 . 36239–50 . October 2012 . 22948142 . 3476291 . 10.1074/jbc.M112.403550 . free .
• Ha BG, Hong JM, Park JY, Ha MH, Kim TH, Cho JY, Ryoo HM, Choi JY, Shin HI, Chun SY, Kim SY, Park EK . Proteomic profile of osteoclast membrane proteins: identification of Na+/H+ exchanger domain containing 2 and its role in osteoclast fusion . Proteomics . 8 . 13 . 2625–39 . July 2008 . 18600791 . 10.1002/pmic.200701192 . 5494045 .
• Huang X, Morse LR, Xu Y, Zahradka J, Sychrová H, Stashenko P, Fan F, Battaglino RA . Mutational analysis of NHAoc/NHA2 in Saccharomyces cerevisiae . Biochimica et Biophysica Acta (BBA) - General Subjects . 1800 . 12 . 1241–7 . December 2010 . 20713131 . 2967667 . 10.1016/j.bbagen.2010.08.001 .
• Fuster DG, Zhang J, Shi M, Bobulescu IA, Andersson S, Moe OW . Characterization of the sodium/hydrogen exchanger NHA2 . Journal of the American Society of Nephrology . 19 . 8 . 1547–56 . August 2008 . 18508966 . 2488271 . 10.1681/ASN.2007111245 .
• Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, Walsh D, Zhao Z, Schuckit M, Nurnberger J, Edenberg H, Kramer J, Hesselbrock V, Tischfield JA, Vladimirov V, Prescott CA, Dick DM, Kendler KS, Riley BP . A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts . Human Molecular Genetics . 19 . 12 . 2497–506 . June 2010 . 20332099 . 2876884 . 10.1093/hmg/ddq112 .
• Battaglino RA, Pham L, Morse LR, Vokes M, Sharma A, Odgren PR, Yang M, Sasaki H, Stashenko P . NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts . Bone . 42 . 1 . 180–92 . January 2008 . 17988971 . 3593247 . 10.1016/j.bone.2007.09.046 .
• Schushan M, Xiang M, Bogomiakov P, Padan E, Rao R, Ben-Tal N . Model-guided mutagenesis drives functional studies of human NHA2, implicated in hypertension . Journal of Molecular Biology . 396 . 5 . 1181–96 . March 2010 . 20053353 . 2824056 . 10.1016/j.jmb.2009.12.055 .

Notes and References

1. Web site: Entrez Gene: Solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 .
2. Xiang M, Feng M, Muend S, Rao R . A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension . Proceedings of the National Academy of Sciences of the United States of America . 104 . 47 . 18677–81 . November 2007 . 18000046 . 2141836 . 10.1073/pnas.0707120104 . 2007PNAS..10418677X . free .