Sodium- and chloride-dependent taurine transporter explained

Sodium- and chloride-dependent taurine transporter is a protein that in humans is encoded by the SLC6A6 gene.^{[1] [2] [3]}

Further reading

• Uchida S, Kwon HM, Yamauchi A, etal . Molecular cloning of the cDNA for an MDCK cell Na(+)- and Cl(−)-dependent taurine transporter that is regulated by hypertonicity. . Proc. Natl. Acad. Sci. U.S.A. . 89 . 17 . 8230–4 . 1992 . 1518851 . 10.1073/pnas.89.17.8230 . 49891 . 1992PNAS...89.8230U . free .
• Miyamoto Y, Liou GI, Sprinkle TJ . Isolation of a cDNA encoding a taurine transporter in the human retinal pigment epithelium. . Curr. Eye Res. . 15 . 3 . 345–9 . 1996 . 8654117 . 10.3109/02713689609007631 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Mochizuki T, Satsu H, Shimizu M . Tumor necrosis factor alpha stimulates taurine uptake and transporter gene expression in human intestinal Caco-2 cells. . FEBS Lett. . 517 . 1–3 . 92–6 . 2002 . 12062416 . 10.1016/S0014-5793(02)02584-X . 86171679 . free .
• Han X, Patters AB, Chesney RW . Transcriptional repression of taurine transporter gene (TauT) by p53 in renal cells . J. Biol. Chem. . 277 . 42 . 39266–73 . 2002 . 12163498 . 10.1074/jbc.M205939200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Han X, Chesney RW . Regulation of taurine transporter gene (TauT) by WT1 . FEBS Lett. . 540 . 1–3 . 71–6 . 2003 . 12681485 . 10.1016/S0014-5793(03)00227-8 . 32139788 . free .
• Roos S, Powell TL, Jansson T . Human placental taurine transporter in uncomplicated and IUGR pregnancies: cellular localization, protein expression, and regulation . Am. J. Physiol. Regul. Integr. Comp. Physiol. . 287 . 4 . R886–93 . 2004 . 15166008 . 10.1152/ajpregu.00232.2004 . 10.1.1.1026.3853 .
• Satsu H, Manabe M, Shimizu M . Activation of Ca2+/calmodulin-dependent protein kinase II is involved in hyperosmotic induction of the human taurine transporter . FEBS Lett. . 569 . 1–3 . 123–8 . 2004 . 15225620 . 10.1016/j.febslet.2004.05.062 . 11395494 . free .
• Mochizuki T, Satsu H, Nakano T, Shimizu M . Regulation of the human taurine transporter by TNF-alpha and an anti-inflammatory function of taurine in human intestinal Caco-2 cells . BioFactors . 21 . 1–4 . 141–4 . 2005 . 15630186 . 10.1002/biof.552210128 . 35504141 .
• Mochizuki T, Satsu H, Shimizu M . Signaling pathways involved in tumor necrosis factor alpha-induced upregulation of the taurine transporter in Caco-2 cells . FEBS Lett. . 579 . 14 . 3069–74 . 2005 . 15907840 . 10.1016/j.febslet.2005.04.063 . 84235462 . free .
• Nakashima E, Pop-Busui R, Towns R, etal . Regulation of the human taurine transporter by oxidative stress in retinal pigment epithelial cells stably transformed to overexpress aldose reductase . Antioxid. Redox Signal. . 7 . 11–12 . 1530–42 . 2006 . 16356117 . 10.1089/ars.2005.7.1530 . 2027.42/63284 . free .
• Iruloh CG, D'Souza SW, Speake PF, etal . Taurine transporter in fetal T lymphocytes and platelets: differential expression and functional activity . Am. J. Physiol., Cell Physiol. . 292 . 1 . C332–41 . 2007 . 16956961 . 10.1152/ajpcell.00634.2005 .

Notes and References

1. Ramamoorthy S, Leibach FH, Mahesh VB, Han H, Yang-Feng T, Blakely RD, Ganapathy V . Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta . Biochem J . 300 . 3. 893–900 . Jul 1994 . 8010975 . 1138249 . 10.1042/bj3000893.
2. Jhiang SM, Fithian L, Smanik P, McGill J, Tong Q, Mazzaferri EL . Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells . FEBS Lett . 318 . 2 . 139–44 . Mar 1993 . 8382624 . 10.1016/0014-5793(93)80008-I . 28368668 .
3. Web site: Entrez Gene: SLC6A6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6.