SLC6A14 explained
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (SLC6A14) is a protein that in humans is encoded by the SLC6A14 gene.[1]
Function
SLC6A14 is a member of the Na+- and Cl−-dependent neurotransmitter transporter family and transports both neutral and cationic amino acids in an Na+- and Cl−-dependent manner.[supplied by OMIM][2]
Further reading
- Ohman M, Oksanen L, Kaprio J, Koskenvuo M, Mustajoki P, Rissanen A, Salmi J, Kontula K, Peltonen L . Genome-wide scan of obesity in Finnish sibpairs reveals linkage to chromosome Xq24 . J. Clin. Endocrinol. Metab. . 85 . 9 . 3183–90 . 2000 . 10.1210/jcem.85.9.6797 . 10999806 . free .
- Sloan JL, Grubb BR, Mager S . Expression of the amino acid transporter ATB 0+ in lung: possible role in luminal protein removal . Am. J. Physiol. Lung Cell Mol. Physiol. . 284 . 1 . L39–49 . 2003 . 12388375 . 10.1152/ajplung.00164.2002 .
- Suviolahti E, Oksanen LJ, Ohman M, Cantor RM, Ridderstrale M, Tuomi T, Kaprio J, Rissanen A, Mustajoki P, Jousilahti P, Vartiainen E, Silander K, Kilpikari R, Salomaa V, Groop L, Kontula K, Peltonen L, Pajukanta P . The SLC6A14 gene shows evidence of association with obesity . J. Clin. Invest. . 112 . 11 . 1762–72 . 2004 . 14660752 . 281637 . 10.1172/JCI17491 .
- Durand E, Boutin P, Meyre D, Charles MA, Clement K, Dina C, Froguel P . Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians . Diabetes . 53 . 9 . 2483–6 . 2004 . 15331564 . 10.2337/diabetes.53.9.2483 . free .
- Gupta N, Miyauchi S, Martindale RG, Herdman AV, Podolsky R, Miyake K, Mager S, Prasad PD, Ganapathy ME, Ganapathy V . Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans . Biochim. Biophys. Acta . 1741 . 1–2 . 215–23 . 2005 . 15905073 . 10.1016/j.bbadis.2005.04.002 .
Notes and References
- Sloan JL, Mager S . Cloning and functional expression of a human Na(+) and Cl(−)-dependent neutral and cationic amino acid transporter B(0+) . J Biol Chem . 274 . 34 . 23740–5 . Sep 1999 . 10446133 . 10.1074/jbc.274.34.23740 . free .
- Web site: Entrez Gene: SLC6A14 solute carrier family 6 (amino acid transporter), member 14.
