SLC5A4 explained

The low affinity sodium-glucose cotransporter also known as the sodium/glucose cotransporter 3 (SGLT3) or solute carrier family 5 member 4 (SLC5A4) is a protein that in humans is encoded by the SLC5A4 gene.^{[1] [2] [3]} It functions as a sugar sensor.

Further reading

• Munafò MR, Clark TG, Roberts KH, Johnstone EC . Neuroticism mediates the association of the serotonin transporter gene with lifetime major depression . Neuropsychobiology . 53 . 1 . 1–8 . 2006 . 16319503 . 10.1159/000089915 . 12803994 .
• Blaya C, Salum GA, Lima MS, Leistner-Segal S, Manfro GG . Lack of association between the Serotonin Transporter Promoter Polymorphism (5-HTTLPR) and Panic Disorder: a systematic review and meta-analysis . Behavioral and Brain Functions . 3 . 41 . 2007 . 17705872 . 1994953 . 10.1186/1744-9081-3-41 . free .
• Diez-Sampedro A, Hirayama BA, Osswald C, Gorboulev V, Baumgarten K, Volk C, Wright EM, Koepsell H . A glucose sensor hiding in a family of transporters . Proceedings of the National Academy of Sciences of the United States of America . 100 . 20 . 11753–8 . September 2003 . 13130073 . 208830 . 10.1073/pnas.1733027100 . 2003PNAS..10011753D . free .
• Fairchild TJ . Protection of muscle membrane excitability during cycling in humans: a role for SGLT3? . Journal of Applied Physiology . 104 . 1 . 315; author reply 316 . January 2008 . 18198291 . 10.1152/japplphysiol.00793.2007 . 29443314 .
• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP . The DNA sequence of human chromosome 22 . Nature . 402 . 6761 . 489–95 . December 1999 . 10591208 . 10.1038/990031 . 1999Natur.402..489D . free .
• Voss AA, Díez-Sampedro A, Hirayama BA, Loo DD, Wright EM . Imino sugars are potent agonists of the human glucose sensor SGLT3 . Molecular Pharmacology . 71 . 2 . 628–34 . February 2007 . 17110502 . 10.1124/mol.106.030288 . 13642065 .

Notes and References

1. Web site: Entrez Gene: solute carrier family 5 (low affinity glucose cotransporter).
2. Veyhl M, Wagner K, Volk C, Gorboulev V, Baumgarten K, Weber WM, Schaper M, Bertram B, Wiessler M, Koepsell H . Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1 . Proceedings of the National Academy of Sciences of the United States of America . 95 . 6 . 2914–9 . March 1998 . 9501190 . 19669 . 10.1073/pnas.95.6.2914 . 1998PNAS...95.2914V . free .
3. Jung H . The sodium/substrate symporter family: structural and functional features . FEBS Letters . 529 . 1 . 73–7 . October 2002 . 12354616 . 10.1016/S0014-5793(02)03184-8 . free .