SLC45A4 explained

SLC45A4 is a member of the SLC45 family of solute carriers. Analysis of the protein function in a recombinant yeast expression assay show that it can: (i) transport a disaccharide, sucrose, as well simple sugars such as glucose and fructose (ii) perform secondary active transport in a proton-dependent manner.^[1]

It is associated with sugar transport in the spermatozoa.^[2] Additionally, it has been identified as a necessary component in the cell death caused of the compound paraquat.^[3]

Notes and References

1. Bartölke R, Heinisch JJ, Wieczorek H, Vitavska O . Proton-associated sucrose transport of mammalian solute carrier family 45: an analysis in Saccharomyces cerevisiae . The Biochemical Journal . 464 . 2 . 193–201 . December 2014 . 25164149 . 10.1042/BJ20140572 .
2. Vitavska O, Wieczorek H . +/sugar cotransporter in mammalian spermatozoa . Pflügers Archiv . 469 . 11 . 1433–1442 . November 2017 . 28689241 . 5629229 . 10.1007/s00424-017-2024-9 .
3. Reczek CR, Birsoy K, Kong H, Martínez-Reyes I, Wang T, Gao P, Sabatini DM, Chandel NS . 6 . A CRISPR screen identifies a pathway required for paraquat-induced cell death . Nature Chemical Biology . 13 . 12 . 1274–1279 . December 2017 . 29058724 . 5698099 . 10.1038/nchembio.2499 .