SLC45A3 explained

Solute carrier family 45 member 3 (SLC45A3), also known as prostate cancer-associated protein 6 or prostein, is a protein that in humans is encoded by the SLC45A3 gene.^{[1] [2] [3]}

SLC45A3 is expressed in a prostate-specific manner by normal tissues and at a significantly lower level in prostate tumor cell lines. Treatment of prostate cancer cell lines with androgens upregulates the expression of SLC45A3.^[3]

Regulation

There is evidence that the expression of SLC45A3 is regulated by the microRNA mir-126*.^[4]

References

Further reading

• Pflueger D, Rickman DS, Sboner A, Perner S, LaFargue CJ, Svensson MA, Moss BJ, Kitabayashi N, Pan Y, de la Taille A, Kuefer R, Tewari AK, Demichelis F, Chee MS, Gerstein MB, Rubin MA . 6 . N-myc downstream regulated gene 1 (NDRG1) is fused to ERG in prostate cancer . Neoplasia . 11 . 8 . 804–11 . August 2009 . 19649210 . 2713587 . 10.1593/neo.09572 .
• Helgeson BE, Tomlins SA, Shah N, Laxman B, Cao Q, Prensner JR, Cao X, Singla N, Montie JE, Varambally S, Mehra R, Chinnaiyan AM . 6 . Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer . Cancer Research . 68 . 1 . 73–80 . January 2008 . 18172298 . 10.1158/0008-5472.CAN-07-5352 . free .
• Esgueva R, Perner S, J LaFargue C, Scheble V, Stephan C, Lein M, Fritzsche FR, Dietel M, Kristiansen G, Rubin MA . 6 . Prevalence of TMPRSS2-ERG and SLC45A3-ERG gene fusions in a large prostatectomy cohort . Modern Pathology . 23 . 4 . 539–46 . April 2010 . 20118910 . 2848699 . 10.1038/modpathol.2009.193 .
• Friedman RS, Spies AG, Kalos M . Identification of naturally processed CD8 T cell epitopes from prostein, a prostate tissue-specific vaccine candidate . European Journal of Immunology . 34 . 4 . 1091–101 . April 2004 . 15048720 . 10.1002/eji.200324768 . free .
• Maher CA, Kumar-Sinha C, Cao X, Kalyana-Sundaram S, Han B, Jing X, Sam L, Barrette T, Palanisamy N, Chinnaiyan AM . 6 . Transcriptome sequencing to detect gene fusions in cancer . Nature . 458 . 7234 . 97–101 . March 2009 . 19136943 . 2725402 . 10.1038/nature07638 . 2009Natur.458...97M .
• Musiyenko A, Bitko V, Barik S . Ectopic expression of miR-126*, an intronic product of the vascular endothelial EGF-like 7 gene, regulates prostein translation and invasiveness of prostate cancer LNCaP cells . Journal of Molecular Medicine . 86 . 3 . 313–22 . March 2008 . 18193184 . 3263384 . 10.1007/s00109-007-0296-9 .
• Kiessling A, Stevanovic S, Füssel S, Weigle B, Rieger MA, Temme A, Rieber EP, Schmitz M . 6 . Identification of an HLA-A*0201-restricted T-cell epitope derived from the prostate cancer-associated protein prostein . British Journal of Cancer . 90 . 5 . 1034–40 . March 2004 . 14997204 . 2410218 . 10.1038/sj.bjc.6601642 .
• Satake W, Nakabayashi Y, Mizuta I, Hirota Y, Ito C, Kubo M, Kawaguchi T, Tsunoda T, Watanabe M, Takeda A, Tomiyama H, Nakashima K, Hasegawa K, Obata F, Yoshikawa T, Kawakami H, Sakoda S, Yamamoto M, Hattori N, Murata M, Nakamura Y, Toda T . 6 . Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease . Nature Genetics . 41 . 12 . 1303–7 . December 2009 . 19915576 . 10.1038/ng.485 . 205356259 .
• Kalos M, Askaa J, Hylander BL, Repasky EA, Cai F, Vedvick T, Reed SG, Wright GL, Fanger GR . 6 . Prostein expression is highly restricted to normal and malignant prostate tissues . The Prostate . 60 . 3 . 246–56 . August 2004 . 15176054 . 10.1002/pros.20043 . 24772512 .
• Sheridan T, Herawi M, Epstein JI, Illei PB . The role of P501S and PSA in the diagnosis of metastatic adenocarcinoma of the prostate . The American Journal of Surgical Pathology . 31 . 9 . 1351–5 . September 2007 . 17721190 . 10.1097/PAS.0b013e3180536678 . 10247840 .

Notes and References

1. Web site: Entrez Gene: solute carrier family 45.
2. Walker MG, Volkmuth W, Sprinzak E, Hodgson D, Klingler T . Prediction of gene function by genome-scale expression analysis: prostate cancer-associated genes . Genome Research . 9 . 12 . 1198–203 . December 1999 . 10613842 . 310991 . 10.1101/gr.9.12.1198 .
3. Xu J, Kalos M, Stolk JA, Zasloff EJ, Zhang X, Houghton RL, Filho AM, Nolasco M, Badaró R, Reed SG . 6 . Identification and characterization of prostein, a novel prostate-specific protein . Cancer Research . 61 . 4 . 1563–8 . February 2001 . 11245466 .
4. Musiyenko A, Bitko V, Barik S . Ectopic expression of miR-126*, an intronic product of the vascular endothelial EGF-like 7 gene, regulates prostein translation and invasiveness of prostate cancer LNCaP cells . Journal of Molecular Medicine . 86 . 3 . 313–22 . March 2008 . 18193184 . 3263384 . 10.1007/s00109-007-0296-9 .