Zinc transporter ZIP6 explained

Zinc transporter ZIP6 is a protein that in humans is encoded by the SLC39A6 gene.^{[1] [2] [3]}

Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003).[supplied by OMIM]

See also

• Solute carrier family

Further reading

• Manning DL, Daly RJ, Lord PG, etal . Effects of oestrogen on the expression of a 4.4 kb mRNA in the ZR-75-1 human breast cancer cell line . Mol. Cell. Endocrinol. . 59 . 3 . 205–12 . 1988 . 2903103 . 10.1016/0303-7207(88)90105-0 . 23701658 .
• Dressman MA, Walz TM, Lavedan C, etal . Genes that co-cluster with estrogen receptor alpha in microarray analysis of breast biopsies . Pharmacogenomics J. . 1 . 2 . 135–41 . 2002 . 11911440 . 10.1038/sj.tpj.6500022. free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Schaner ME, Ross DT, Ciaravino G, etal . Gene expression patterns in ovarian carcinomas . Mol. Biol. Cell . 14 . 11 . 4376–86 . 2004 . 12960427 . 10.1091/mbc.E03-05-0279 . 266758 .
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites . Protein Sci. . 13 . 10 . 2819–24 . 2005 . 15340161 . 10.1110/ps.04682504 . 2286551 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Kasper G, Weiser AA, Rump A, etal . Expression levels of the putative zinc transporter LIV-1 are associated with a better outcome of breast cancer patients . Int. J. Cancer . 117 . 6 . 961–73 . 2005 . 15986450 . 10.1002/ijc.21235 . 43808796 .
• Zhao L, Chen W, Taylor KM, etal . LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway . Biochem. Biophys. Res. Commun. . 363 . 1 . 82–8 . 2007 . 17825787 . 10.1016/j.bbrc.2007.08.127 .

Notes and References

1. Taylor KM, Nicholson RI . The LZT proteins; the LIV-1 subfamily of zinc transporters . Biochim Biophys Acta . 1611 . 1–2 . 16–30 . Mar 2003 . 12659941 . 10.1016/S0005-2736(03)00048-8 . free .
2. Taylor KM, Morgan HE, Johnson A, Hadley LJ, Nicholson RI . Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters . Biochem J . 375 . Pt 1 . 51–9 . Sep 2003 . 12839489 . 1223660 . 10.1042/BJ20030478 .
3. Web site: Entrez Gene: SLC39A6 solute carrier family 39 (zinc transporter), member 6.