Glucose-6-phosphate exchanger SLC37A1 explained

Glucose-6-phosphate exchanger SLC37A1 is a protein that in humans is encoded by the SLC37A1 gene.^[1] SLC37A1 locates to the membrane of the endoplasmic reticulum (ER), and is a glucose 6-phosphate:inorganic phosphate antiporter, transporting glucose 6-phosphate from the cytoplasm into the lumen of the ER, while transporting phosphate in the opposite direction.^[2]

Unlike the related SLC37A4 protein, SLC37A1 does not appear to be involved in blood glucose homeostasis,^[3] but does appear to regulate phosphate levels in the milk of cows, with flow-on effects on the volume of milk produced.^[4]

Further reading

• Bartoloni L, Antonarakis SE . The human sugar-phosphate/phosphate exchanger family SLC37 . Pflügers Archiv . 447 . 5 . 780–3 . February 2004 . 12811562 . 10.1007/s00424-003-1105-0 . 24776306 .

Notes and References

1. Web site: Entrez Gene: Solute carrier family 37 (glucose-6-phosphate transporter), member 1 .
2. Web site: SLC37A1 - Glucose-6-phosphate exchanger SLC37A1 - Homo sapiens (Human) - SLC37A1 gene & protein .
3. Pan CJ, Chen SY, Jun HS, Lin SR, Mansfield BC, Chou JY . SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters . PLOS ONE . 6 . 9 . e23157 . 2011 . 21949678 . 3176764 . 10.1371/journal.pone.0023157 . 2011PLoSO...623157P . free .
4. Kemper KE, Littlejohn MD, Lopdell T, Hayes BJ, Bennett LE, Williams RP, Xu XQ, Visscher PM, Carrick MJ, Goddard ME . Leveraging genetically simple traits to identify small-effect variants for complex phenotypes . BMC Genomics . 17 . 858 . 2016 . 1 . 27809761 . 5094043 . 10.1186/s12864-016-3175-3 . free .