Proton-coupled amino acid transporter 1 explained

Proton-coupled amino acid transporter 1 is a protein that in humans is encoded by the SLC36A1 gene.^{[1] [2] [3]}

This gene encodes a member of the eukaryote-specific amino acid/auxin permease (AAAP) 1 transporter family. The encoded protein functions as a proton-dependent, small amino acid transporter. This gene is clustered with related family members on chromosome 5q33.1.^[3]

See also

• Solute carrier family
• Proton coupled amino acid transporter

Further reading

• Hartley JL, Temple GF, Brasch MA . DNA Cloning Using In Vitro Site-Specific Recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Wiemann S, Weil B, Wellenreuther R, etal . Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 .
• Simpson JC, Wellenreuther R, Poustka A, etal . Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing . EMBO Rep. . 1 . 3 . 287–92 . 2001 . 11256614 . 10.1093/embo-reports/kvd058 . 1083732 .
• Chen Z, Fei YJ, Anderson CM, etal . Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2 . J. Physiol. . 546 . Pt 2 . 349–61 . 2003 . 12527723 . 10.1113/jphysiol.2002.026500 . 2342508 .
• Wreden CC, Johnson J, Tran C, etal . The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons . J. Neurosci. . 23 . 4 . 1265–75 . 2003 . 12598615 . 10.1523/JNEUROSCI.23-04-01265.2003. 6742289 .
• Boll M, Foltz M, Rubio-Aliaga I, Daniel H . A cluster of proton/amino acid transporter genes in the human and mouse genomes . Genomics . 82 . 1 . 47–56 . 2004 . 12809675 . 10.1016/S0888-7543(03)00099-5 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Bermingham JR, Pennington J . Organization and expression of the SLC36 cluster of amino acid transporter genes . Mamm. Genome . 15 . 2 . 114–25 . 2004 . 15058382 . 10.1007/s00335-003-2319-3 . 21418124 .
• Wiemann S, Arlt D, Huber W, etal . From ORFeome to Biology: A Functional Genomics Pipeline . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 .
• Anderson CM, Grenade DS, Boll M, etal . H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat . Gastroenterology . 127 . 5 . 1410–22 . 2004 . 15521011 . 10.1053/j.gastro.2004.08.017 . free .
• Anderson CM, Thwaites DT . Indirect regulation of the intestinal H+-coupled amino acid transporter hPAT1 (SLC36A1) . J. Cell. Physiol. . 204 . 2 . 604–13 . 2005 . 15754324 . 10.1002/jcp.20337 . 31443973 .
• Abbot EL, Grenade DS, Kennedy DJ, etal . Vigabatrin transport across the human intestinal epithelial (Caco-2) brush-border membrane is via the H+-coupled amino-acid transporter hPAT1 . Br. J. Pharmacol. . 147 . 3 . 298–306 . 2006 . 16331283 . 10.1038/sj.bjp.0706557 . 1751303 .
• Mehrle A, Rosenfelder H, Schupp I, etal . The LIFEdb database in 2006 . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 .
• Kuan YH, Gruebl T, Soba P, etal . PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2 . J. Biol. Chem. . 281 . 52 . 40114–23 . 2007 . 17050537 . 10.1074/jbc.M605407200 . free .

Notes and References

1. Boll M, Foltz M, Rubio-Aliaga I, Kottra G, Daniel H . Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters . J Biol Chem . 277 . 25 . 22966–73 . Jun 2002 . 11959859 . 10.1074/jbc.M200374200 . free .
2. Sagne C, Agulhon C, Ravassard P, Darmon M, Hamon M, El Mestikawy S, Gasnier B, Giros B . Identification and characterization of a lysosomal transporter for small neutral amino acids . Proc Natl Acad Sci U S A . 98 . 13 . 7206–11 . Jun 2001 . 11390972 . 34647 . 10.1073/pnas.121183498 . 2001PNAS...98.7206S . free .
3. Web site: Entrez Gene: SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1.