Sodium-dependent phosphate transport protein 2B explained

Sodium-dependent phosphate transport protein 2B (NaPi2b) is a protein that in humans is encoded by the SLC34A2 gene.^{[1] [2] [3]}

Clinical significance

Sodium-dependent phosphate transport protein 2b (NaPi2b) is a tumor-associated antigen.^[4]

As of April 2023, upifitamab rilsodotin, an antibody-drug conjugate (ADC) targeting NaPi2b, is in Phase 3 clinical trials for recurrent platinum-sensitive ovarian cancer.

See also

• Solute carrier family
• Pulmonary alveolar microlithiasis

Further reading

• Xu H, Collins JF, Bai L, Kiela PR, Ghishan FK . Regulation of the human sodium-phosphate cotransporter NaP(i)-IIb gene promoter by epidermal growth factor . American Journal of Physiology. Cell Physiology . 280 . 3 . C628–C636 . March 2001 . 11171583 . 10.1152/ajpcell.2001.280.3.C628 . 7439508 .
• Segawa H, Kaneko I, Takahashi A, Kuwahata M, Ito M, Ohkido I, Tatsumi S, Miyamoto K . 6 . Growth-related renal type II Na/Pi cotransporter . The Journal of Biological Chemistry . 277 . 22 . 19665–19672 . May 2002 . 11880379 . 10.1074/jbc.M200943200 . free .
• Xu H, Uno JK, Inouye M, Collins JF, Ghishan FK . NF1 transcriptional factor(s) is required for basal promoter activation of the human intestinal NaPi-IIb cotransporter gene . American Journal of Physiology. Gastrointestinal and Liver Physiology . 288 . 2 . G175–G181 . February 2005 . 15458926 . 10.1152/ajpgi.00396.2004 . 14194207 .
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T . 6 . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries . DNA Research . 12 . 2 . 117–126 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . free .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . 6 . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . January 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Corut A, Senyigit A, Ugur SA, Altin S, Ozcelik U, Calisir H, Yildirim Z, Gocmen A, Tolun A . 6 . Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis . American Journal of Human Genetics . 79 . 4 . 650–656 . October 2006 . 16960801 . 1592565 . 10.1086/508263 .
• Izumi S, Miyazawa H, Ishii K, Uchiyama B, Ishida T, Tanaka S, Tazawa R, Fukuyama S, Tanaka T, Nagai Y, Yokote A, Takahashi H, Fukushima T, Kobayashi K, Chiba H, Nagata M, Sakamoto S, Nakata K, Takebayashi Y, Shimizu Y, Kaneko K, Shimizu M, Kanazawa M, Abe S, Inoue Y, Takenoshita S, Yoshimura K, Kudo K, Tachibana T, Nukiwa T, Hagiwara K . 6 . Mutations in the SLC34A2 gene are associated with pulmonary alveolar microlithiasis . American Journal of Respiratory and Critical Care Medicine . 175 . 3 . 263–268 . February 2007 . 17095743 . 10.1164/rccm.200609-1274OC .

Notes and References

1. Feild JA, Zhang L, Brun KA, Brooks DP, Edwards RM . Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestine . Biochemical and Biophysical Research Communications . 258 . 3 . 578–582 . May 1999 . 10329428 . 10.1006/bbrc.1999.0666 .
2. Xu H, Bai L, Collins JF, Ghishan FK . Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium-phosphate (Na+-Pi) transporter (SLC34A2) . Genomics . 62 . 2 . 281–284 . December 1999 . 10610722 . 10.1006/geno.1999.6009 .
3. Web site: Entrez Gene: SLC34A2 solute carrier family 34 (sodium phosphate), member 2.
4. Yin BW, Kiyamova R, Chua R, Caballero OL, Gout I, Gryshkova V, Bhaskaran N, Souchelnytskyi S, Hellman U, Filonenko V, Jungbluth AA, Odunsi K, Lloyd KO, Old LJ, Ritter G . 6 . Monoclonal antibody MX35 detects the membrane transporter NaPi2b (SLC34A2) in human carcinomas . Cancer Immunity . 8 . 3 . February 2008 . 18251464 . 2935786 .