Zinc transporter 4 explained

Zinc transporter 4 is a protein that in humans is encoded by the SLC30A4 gene.^[1]

See also

• Solute carrier family

Further reading

• Huang L, Gitschier J . A novel gene involved in zinc transport is deficient in the lethal milk mouse. . Nat. Genet. . 17 . 3 . 292–7 . 1997 . 9354792 . 10.1038/ng1197-292 . 8000689 .
• Murgia C, Vespignani I, Cerase J, etal . Cloning, expression, and vesicular localization of zinc transporter Dri 27/ZnT4 in intestinal tissue and cells. . Am. J. Physiol. . 277 . 6 Pt 1 . G1231–9 . 2000 . 10.1152/ajpgi.1999.277.6.G1231 . 10600821 . 31257828 .
• Küry S, Devilder MC, Avet-Loiseau H, etal . Expression pattern, genomic structure and evaluation of the human SLC30A4 gene as a candidate for acrodermatitis enteropathica. . Hum. Genet. . 109 . 2 . 178–85 . 2001 . 11511923 . 10.1007/s004390100539 . 11501283 .
• Bleck O, Ashton GH, Mallipeddi R, etal . Genomic localization, organization and amplification of the human zinc transporter protein gene, ZNT4, and exclusion as a candidate gene in different clinical variants of acrodermatitis enteropathica. . Arch. Dermatol. Res. . 293 . 8 . 392–6 . 2002 . 11686514 . 10.1007/s004030100246 . 13027648 .
• Nakano A, Nakano H, Hanada K, etal . ZNT4 gene is not responsible for acrodermatitis enteropathica in Japanese families. . Hum. Genet. . 110 . 2 . 201–2 . 2002 . 11935329 . 10.1007/s00439-001-0661-7 . 37006354 .
• Michalczyk AA, Allen J, Blomeley RC, Ackland ML . Constitutive expression of hZnT4 zinc transporter in human breast epithelial cells . Biochem. J. . 364 . Pt 1 . 105–13 . 2002 . 10.1042/bj3640105 . 11988082 . 1222551 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Michalczyk A, Varigos G, Catto-Smith A, etal . Analysis of zinc transporter, hZnT4 (Slc30A4), gene expression in a mammary gland disorder leading to reduced zinc secretion into milk . Hum. Genet. . 113 . 3 . 202–10 . 2003 . 12743795 . 10.1007/s00439-003-0952-2 . 36141272 .
• Henshall SM, Afar DE, Rasiah KK, etal . Expression of the zinc transporter ZnT4 is decreased in the progression from early prostate disease to invasive prostate cancer . Oncogene . 22 . 38 . 6005–12 . 2003 . 12955079 . 10.1038/sj.onc.1206797 . free .
• Beck FW, Prasad AS, Butler CE, etal . Differential expression of hZnT-4 in human prostate tissues . Prostate . 58 . 4 . 374–81 . 2004 . 14968438 . 10.1002/pros.10344 . 24889031 .
• Ho LH, Ruffin RE, Murgia C, etal . Labile zinc and zinc transporter ZnT4 in mast cell granules: role in regulation of caspase activation and NF-kappaB translocation . J. Immunol. . 172 . 12 . 7750–60 . 2004 . 15187159 . 10.4049/jimmunol.172.12.7750. free .
• Smith JL, Xiong S, Markesbery WR, Lovell MA . Altered expression of zinc transporters-4 and -6 in mild cognitive impairment, early and late Alzheimer's disease brain . Neuroscience . 140 . 3 . 879–88 . 2006 . 16580781 . 10.1016/j.neuroscience.2006.02.049 . 29807730 .

Notes and References

1. Web site: Entrez Gene: SLC30A4 solute carrier family 30 (zinc transporter), member 4.