Zinc transporter 3 explained

Zinc transporter 3 also known as solute carrier family 30 member 3 is a protein in humans that is encoded by the SLC30A3 gene.^[1]

The SLC30A3 gene codes for the ZnT-3 SLC30A family membrane transport protein. ZnT-3 is required for the accumulation of zinc ions inside synaptic vesicles.^[2] In mice, ZnT-3 is required for some forms of memory that depend on the hippocampus and the amygdala.^[3] Zinc transport by ZnT-3 modulates memory formation by acting through the extracellular signal-regulated kinases signaling pathway.^[4] Angiotensin II-induced senescence of vascular smooth muscle cells requires down-regulation of ZnT-3 and ZnT-10.^[5]

See also

• Solute carrier family

Notes and References

1. Web site: Entrez Gene: Solute carrier family 30 (zinc transporter), member 3 .
2. Cole TB, Wenzel HJ, Kafer KE, Schwartzkroin PA, Palmiter RD . Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene . Proceedings of the National Academy of Sciences of the United States of America . 96 . 4 . 1716–21 . February 1999 . 9990090 . 15571 . 10.1073/pnas.96.4.1716 . 1999PNAS...96.1716C . free .
3. Sindreu C, Storm DR . Modulation of neuronal signal transduction and memory formation by synaptic zinc . Frontiers in Behavioral Neuroscience . 5 . 68 . 2011 . 22084630 . 3211062 . 10.3389/fnbeh.2011.00068 . free .
4. Mott DD, Dingledine R . Unraveling the role of zinc in memory . Proceedings of the National Academy of Sciences of the United States of America . 108 . 8 . 3103–4 . February 2011 . 21321213 . 3044369 . 10.1073/pnas.1100323108 . 2011PNAS..108.3103M . free .
5. Patrushev N, Seidel-Rogol B, Salazar G . Angiotensin II requires zinc and downregulation of the zinc transporters ZnT3 and ZnT10 to induce senescence of vascular smooth muscle cells . PLOS ONE . 7 . 3 . e33211 . 2012 . 22427991 . 3299759 . 10.1371/journal.pone.0033211 . 2012PLoSO...733211P . free .