Zinc transporter 1 explained

Zinc transporter 1 is a protein which in humans is encoded by the SLC30A1 gene.^{[1] [2]}

Function

SLC30A1 modulates zinc permeation through the L-type calcium channel. SLC30A1 downregulates not only Zn⁺⁺ influx, but also Ca⁺⁺ influx, thereby protecting cells from the effects of excessive cation permeation.^[3]

See also

• Solute carrier family

Further reading

• Guey LT, GarcÃa-Closas M, Murta-Nascimento C, etal . Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes. . Eur. Urol. . 57. 2. 283–292 . 2009 . 19692168 . 10.1016/j.eururo.2009.08.001 . 3220186.
• Zhang LH, Wang X, Stoltenberg M, etal . Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain. . Brain Res. Bull. . 77 . 1 . 55–60 . 2008 . 18639746 . 10.1016/j.brainresbull.2008.03.014 . 33951242 .
• Lovell MA, Smith JL, Xiong S, Markesbery WR . Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage Alzheimer's disease. . Neurotoxicity Research . 7 . 4 . 265–71 . 2005 . 16179263 . 10.1007/BF03033884 . 11433 .
• Zhang LY, Wang XL, Sun DX, etal . Regulation of zinc transporters by dietary flaxseed lignan in human breast cancer xenografts. . Mol. Biol. Rep. . 35 . 4 . 595–600 . 2008 . 17786585 . 10.1007/s11033-007-9129-8 . 2490974 .
• Iguchi K, Otsuka T, Usui S, etal . Zinc and metallothionein levels and expression of zinc transporters in androgen-independent subline of LNCaP cells. . J. Androl. . 25 . 1 . 154–61 . 2004. 14662799 . 10.1002/j.1939-4640.2004.tb02771.x. free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Lazarczyk M, Pons C, Mendoza JA, etal . Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses. . J. Exp. Med. . 205 . 1 . 35–42 . 2008 . 18158319 . 10.1084/jem.20071311 . 2234378 .
• Overbeck S, Uciechowski P, Ackland ML, etal . Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9. . J. Leukoc. Biol. . 83 . 2 . 368–80 . 2008 . 17971500 . 10.1189/jlb.0307148 . 21801798 .
• Hosgood HD, Menashe I, He X, etal . PTEN identified as important risk factor of chronic obstructive pulmonary disease. . Respiratory Medicine . 103. 12. 1866–1870 . 2009 . 19625176 . 10.1016/j.rmed.2009.06.016 . 2783799 .
• Hosgood HD, Menashe I, Shen M, etal . Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. . Carcinogenesis . 29 . 10 . 1938–43 . 2008 . 18676680 . 10.1093/carcin/bgn178 . 2722857 .
• Etzion Y, Ganiel A, Beharier O, etal . Correlation between atrial ZnT-1 expression and atrial fibrillation in humans: a pilot study. . J. Cardiovasc. Electrophysiol. . 19 . 2 . 157–64 . 2008 . 17971132 . 10.1111/j.1540-8167.2007.01008.x . 8430908 .
• Barbe L, Lundberg E, Oksvold P, etal . Toward a confocal subcellular atlas of the human proteome. . Mol. Cell. Proteomics . 7 . 3 . 499–508 . 2008 . 18029348 . 10.1074/mcp.M700325-MCP200 . free .

Notes and References

1. Palmiter RD, Findley SD . Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc . The EMBO Journal . 14 . 4 . 639–49 . February 1995 . 7882967 . 398127 . 10.1002/j.1460-2075.1995.tb07042.x.
2. Seve M, Chimienti F, Devergnas S, Favier A . In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression . BMC Genomics . 5 . 32 . May 2004 . 15154973 . 428573 . 10.1186/1471-2164-5-32 . 1 . free .
3. Segal D, Ohana E, Besser L, Hershfinkel M, Moran A, Sekler I . A role for ZnT-1 in regulating cellular cation influx . Biochemical and Biophysical Research Communications . 323 . 4 . 1145–50 . October 2004 . 15451416 . 10.1016/j.bbrc.2004.08.211 .