SLC2A9 explained

Solute carrier family 2, facilitated glucose transporter member 9 is a protein that in humans is encoded by the SLC2A9 gene.^{[1] [2] [3]}

This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene.^[3]

SLC2A9 has also recently been found to transport uric acid, and genetic variants of the transporter have been linked to increased risk of development of both hyperuricemia, gout and Alzheimer's disease.^{[4] [5] [6]}

See also

• Glucose transporter
• Solute carrier family

Further reading

• Doege H, Bocianski A, Joost HG, Schürmann A . Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes. . 350 . Biochem. J. . Pt 3 . 3. 771–6 . 2001 . 10970791 . 10.1042/0264-6021:3500771. 1221309 .
• Shikhman AR, Brinson DC, Valbracht J, Lotz MK . Cytokine regulation of facilitated glucose transport in human articular chondrocytes. . J. Immunol. . 167 . 12 . 7001–8 . 2001 . 11739520 . 10.4049/jimmunol.167.12.7001. free .
• Mobasheri A, Neama G, Bell S, etal . Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9. . Cell Biol. Int. . 26 . 3 . 297–300 . 2002 . 11991658 . 10.1006/cbir.2001.0850 . 34492031 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Richardson S, Neama G, Phillips T, etal . Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation. . Osteoarthr. Cartil. . 11 . 2 . 92–101 . 2003 . 12554125 . 10.1053/joca.2002.0858 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Augustin R, Carayannopoulos MO, Dowd LO, etal . Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking. . J. Biol. Chem. . 279 . 16 . 16229–36 . 2004 . 14739288 . 10.1074/jbc.M312226200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .

Notes and References

1. Phay JE, Hussain HB, Moley JF . Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9) . Genomics . 66 . 2 . 217–20 . Aug 2000 . 10860667 . 10.1006/geno.2000.6195 .
2. Manolescu AR, Augustin R, Moley K, Cheeseman C . A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity . Mol Membr Biol . 24 . 5–6 . 455–63 . Aug 2007 . 17710649 . 10.1080/09687680701298143 . 35331716 . free .
3. Web site: SLC2A9 solute carrier family 2 member 9 [Homo sapiens (human) ] ].
4. Vitart V, Rudan I, Hayward C, etal . SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout . Nature Genetics . 40 . 4 . 437–42. 2008 . 18327257. 10.1038/ng.106 . 6720464 .
5. Döring A, Gieger C, Mehta D, etal . SLC2A9 influences uric acid concentrations with pronounced sex-specific effects . Nature Genetics . 40 . 4 . 430–6. 2008 . 18327256. 10.1038/ng.107 . 29751482 .
6. Hollingworth P, Sweet R, Sims R, etal . Genome-wide association study of Alzheimer's disease with psychotic symptoms . Molecular Psychiatry . 17 . 12 . 1316–1327 . 2012 . 10.1038/mp.2011.125. 22005930 . 3272435 .