Concentrative nucleoside transporter 2 explained

Concentrative nucleoside transporter 2 (CNT2) is a protein that in humans is encoded by the SLC28A2 gene.^{[1] [2]}

See also

• Concentrative nucleoside transporters
• Nucleoside transporters
• Solute carrier family

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Ritzel MW, Yao SY, Ng AM . Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine. . Mol. Membr. Biol. . 15 . 4 . 203–11 . 1999 . 10087507 . 10.3109/09687689709044322 . etal. free .
• Loewen SK, Ng AM, Yao SY . Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2. . J. Biol. Chem. . 274 . 35 . 24475–84 . 1999 . 10455109 . 10.1074/jbc.274.35.24475 . etal. free .
• Pennycooke M, Chaudary N, Shuralyova I . Differential expression of human nucleoside transporters in normal and tumor tissue. . Biochem. Biophys. Res. Commun. . 280 . 3 . 951–9 . 2001 . 11162617 . 10.1006/bbrc.2000.4205 . etal.
• Li JY, Boado RJ, Pardridge WM . Differential kinetics of transport of 2',3'-dideoxyinosine and adenosine via concentrative Na+ nucleoside transporter CNT2 cloned from rat blood–brain barrier. . J. Pharmacol. Exp. Ther. . 299 . 2 . 735–40 . 2001 . 11602688 .
• Gerstin KM, Dresser MJ, Giacomini KM . Specificity of human and rat orthologs of the concentrative nucleoside transporter, SPNT. . Am. J. Physiol. Renal Physiol. . 283 . 2 . F344–9 . 2002 . 12110519 . 10.1152/ajprenal.00274.2001 . 21332585 .
• Molina-Arcas M, Bellosillo B, Casado FJ . Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia. . Blood . 101 . 6 . 2328–34 . 2003 . 12411296 . 10.1182/blood-2002-07-2236 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . etal. free .
• Shin HC, Landowski CP, Sun D . Functional expression and characterization of a sodium-dependent nucleoside transporter hCNT2 cloned from human duodenum. . Biochem. Biophys. Res. Commun. . 307 . 3 . 696–703 . 2003 . 12893280 . 10.1016/S0006-291X(03)01259-2 . etal.
• Lang TT, Young JD, Cass CE . Interactions of nucleoside analogs, caffeine, and nicotine with human concentrative nucleoside transporters 1 and 2 stably produced in a transport-defective human cell line. . Mol. Pharmacol. . 65 . 4 . 925–33 . 2004 . 15044622 . 10.1124/mol.65.4.925 . 5665725 .
• Damaraju VL, Visser F, Zhang J . Role of human nucleoside transporters in the cellular uptake of two inhibitors of IMP dehydrogenase, tiazofurin and benzamide riboside. . Mol. Pharmacol. . 67 . 1 . 273–9 . 2005 . 15486050 . 10.1124/mol.104.004408 . 3017992 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928. etal.
• Owen RP, Gray JH, Taylor TR . Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2. . Pharmacogenet. Genomics . 15 . 2 . 83–90 . 2005 . 15861032 . 10.1097/01213011-200502000-00004 . 12817964 . etal.
• Owen RP, Badagnani I, Giacomini KM . Molecular determinants of specificity for synthetic nucleoside analogs in the concentrative nucleoside transporter, CNT2. . J. Biol. Chem. . 281 . 36 . 26675–82 . 2006 . 16840788 . 10.1074/jbc.M513421200 . free .
• Fernández-Veledo S, Jover R, Casado FJ . Transcription factors involved in the expression of SLC28 genes in human liver parenchymal cells. . Biochem. Biophys. Res. Commun. . 353 . 2 . 381–8 . 2007 . 17187757 . 10.1016/j.bbrc.2006.12.021 . etal.
• Smith KM, Slugoski MD, Cass CE . Cation coupling properties of human concentrative nucleoside transporters hCNT1, hCNT2 and hCNT3. . Mol. Membr. Biol. . 24 . 1 . 53–64 . 2007 . 17453413 . 10.1080/09687860600942534 . 20779608 . etal.
• Hirsh AJ, Stonebraker JR, van Heusden CA . Adenosine deaminase 1 and concentrative nucleoside transporters 2 and 3 regulate adenosine on the apical surface of human airway epithelia: implications for inflammatory lung diseases. . Biochemistry . 46 . 36 . 10373–83 . 2007 . 17696452 . 10.1021/bi7009647 . etal.
• Li L, Tan CM, Koo SH . Identification and functional analysis of variants in the human concentrative nucleoside transporter 2, hCNT2 (SLC28A2) in Chinese, Malays and Indians. . Pharmacogenet. Genomics . 17 . 9 . 783–6 . 2007 . 17700367 . 10.1097/FPC.0b013e3281c10e41 . etal.

Notes and References

1. Wang J, Su SF, Dresser MJ, Schaner ME, Washington CB, Giacomini KM . Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization . Am J Physiol . 273 . 6 Pt 2 . F1058-65 . Feb 1998 . 9435697 . 10.1152/ajprenal.1997.273.6.F1058.
2. Web site: Entrez Gene: SLC28A2 solute carrier family 28 (sodium-coupled nucleoside transporter), member 2.