Long-chain fatty acid transport protein 4 explained

Long-chain fatty acid transport protein 4 is a protein that in humans is encoded by the SLC27A4 gene.^{[1] [2]} This membrane protein is also called FATP4 or ACSVL5 (very long chain fatty acyl-CoA synthetase 5). The purified protein shows enzyme activity (EC 6.2.1.3), esterifying long and very long chain fatty acids with Coenzyme A.^[3] It is debated whether it is also a fatty acid transporter at the plasma membrane.^[4]

See also

• Solute carrier family

Further reading

• Hirsch D, Stahl A, Lodish HF . A family of fatty acid transporters conserved from mycobacterium to man . Proceedings of the National Academy of Sciences of the United States of America . 95 . 15 . 8625–9 . Jul 1998 . 9671728 . 21126 . 10.1073/pnas.95.15.8625 . 1998PNAS...95.8625H . free .
• Stahl A, Hirsch DJ, Gimeno RE, Punreddy S, Ge P, Watson N, Patel S, Kotler M, Raimondi A, Tartaglia LA, Lodish HF . Identification of the major intestinal fatty acid transport protein . Molecular Cell . 4 . 3 . 299–308 . Sep 1999 . 10518211 . 10.1016/S1097-2765(00)80332-9 . free .
• Gertow K, Bellanda M, Eriksson P, Boquist S, Hamsten A, Sunnerhagen M, Fisher RM . Genetic and structural evaluation of fatty acid transport protein-4 in relation to markers of the insulin resistance syndrome . The Journal of Clinical Endocrinology and Metabolism . 89 . 1 . 392–9 . Jan 2004 . 14715877 . 10.1210/jc.2003-030682 . free . 11577/1331563 . free .
• Gertow K, Pietiläinen KH, Yki-Järvinen H, Kaprio J, Rissanen A, Eriksson P, Hamsten A, Fisher RM . Expression of fatty-acid-handling proteins in human adipose tissue in relation to obesity and insulin resistance . Diabetologia . 47 . 6 . 1118–25 . Jun 2004 . 15168018 . 10.1007/s00125-004-1417-4 . free .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
• Milger K, Herrmann T, Becker C, Gotthardt D, Zickwolf J, Ehehalt R, Watkins PA, Stremmel W, Füllekrug J . Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4 . Journal of Cell Science . 119 . Pt 22 . 4678–88 . Nov 2006 . 17062637 . 10.1242/jcs.03280 . free .

Notes and References

1. Fitscher BA, Riedel HD, Young KC, Stremmel W . Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4) . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1443 . 3 . 381–5 . Dec 1998 . 9878842 . 10.1016/s0167-4781(98)00231-0 .
2. Web site: Entrez Gene: SLC27A4 solute carrier family 27 (fatty acid transporter), member 4.
3. Hall AM, Wiczer BM, Herrmann T, Stremmel W, Bernlohr DA . Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice . The Journal of Biological Chemistry . 280 . 12 . 11948–54 . Mar 2005 . 15653672 . 10.1074/jbc.M412629200 . free .
4. Watkins PA . Very-long-chain acyl-CoA synthetases . The Journal of Biological Chemistry . 283 . 4 . 1773–7 . Jan 2008 . 18024425 . 10.1074/jbc.R700037200 . free .