Long-chain fatty acid transport protein 1 explained

Long-chain fatty acid transport protein 1 (FATP1) is a protein that in humans is encoded by the SLC27A1 gene.^{[1] [2]}

Structure

The SLC27A1 gene is located on the 19th chromosome, with its specific location being 19p13.11. The gene contains 15 exons. SLC27A1 encodes a 71.1 kDa protein that is composed of 646 amino acids; 26 peptides have been observed through mass spectrometry data.^[3]

See also

• • Solute carrier family

Further reading

• Meirhaeghe A, Cottel D, Amouyel P, Dallongeville J . Lack of association between certain candidate gene polymorphisms and the metabolic syndrome . Molecular Genetics and Metabolism . 86 . 1–2 . 293–9 . 2006 . 15978856 . 10.1016/j.ymgme.2005.05.006 .
• García-Martínez C, Marotta M, Moore-Carrasco R, Guitart M, Camps M, Busquets S, Montell E, Gómez-Foix AM . Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells . American Journal of Physiology. Cell Physiology . 288 . 6 . C1264-72 . June 2005 . 15897321 . 10.1152/ajpcell.00271.2004 .
• Gertow K, Skoglund-Andersson C, Eriksson P, Boquist S, Orth-Gomér K, Schenck-Gustafsson K, Hamsten A, Fisher RM . A common polymorphism in the fatty acid transport protein-1 gene associated with elevated post-prandial lipaemia and alterations in LDL particle size distribution . Atherosclerosis . 167 . 2 . 265–73 . April 2003 . 12818409 . 10.1016/S0021-9150(02)00454-9 .
• Hatch GM, Smith AJ, Xu FY, Hall AM, Bernlohr DA . FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells . Journal of Lipid Research . 43 . 9 . 1380–9 . September 2002 . 12235169 . 10.1194/jlr.M200130-JLR200 . free .
• Hirsch D, Stahl A, Lodish HF . A family of fatty acid transporters conserved from mycobacterium to man . Proceedings of the National Academy of Sciences of the United States of America . 95 . 15 . 8625–9 . July 1998 . 9671728 . 21126 . 10.1073/pnas.95.15.8625 . 1998PNAS...95.8625H . free .
• Schaffer JE, Lodish HF . Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein . Cell . 79 . 3 . 427–36 . November 1994 . 7954810 . 10.1016/0092-8674(94)90252-6 . 20637905 .

Notes and References

1. Martin G, Nemoto M, Gelman L, Geffroy S, Najib J, Fruchart JC, Roevens P, de Martinville B, Deeb S, Auwerx J . The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression . Genomics . 66 . 3 . 296–304 . June 2000 . 10873384 . 10.1006/geno.2000.6191 .
2. Web site: Entrez Gene: SLC27A1 solute carrier family 27 (fatty acid transporter), member 1.
3. Web site: Long-chain fatty acid transport protein 1. Cardiac Organellar Protein Atlas Knowledgebase (COPaKB) .