SLC26A6 explained

Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene.^{[1] [2] [3]} It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.^[4]

This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Several alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been described, but the full-length nature of some of these variants has not been determined.^[3]

Associated diseases

Diseases associated with SLC26A6 include sialolithiasis and urolithiasis.^[5]

See also

• Solute carrier family

Further reading

• Markovich D . Physiological roles and regulation of mammalian sulfate transporters. . Physiol. Rev. . 81 . 4 . 1499–533 . 2001 . 11581495 . 10.1152/physrev.2001.81.4.1499. 30942862 .
• Ignatovich O, Tomlinson IM, Popov AV, etal . Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vlambda repertoire. . J. Mol. Biol. . 294 . 2 . 457–65 . 2000 . 10610771 . 10.1006/jmbi.1999.3243 .
• Xie Q, Welch R, Mercado A, etal . Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1. . Am. J. Physiol. Renal Physiol. . 283 . 4 . F826–38 . 2002 . 12217875 . 10.1152/ajprenal.00079.2002 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Chernova MN, Jiang L, Friedman DJ, etal . Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity. . J. Biol. Chem. . 280 . 9 . 8564–80 . 2005 . 15548529 . 10.1074/jbc.M411703200 . free .
• Kujala M, Tienari J, Lohi H, etal . SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney. . Nephron Exp. Nephrol. . 101 . 2 . e50–8 . 2006 . 15956810 . 10.1159/000086345 . 26671784 .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Shcheynikov N, Wang Y, Park M, etal . Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6. . J. Gen. Physiol. . 127 . 5 . 511–24 . 2006 . 16606687 . 10.1085/jgp.200509392 . 2151520 .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Book: Alper SL, Stewart AK, Chernova MN, etal . Epithelial Anion Transport in Health and Disease: The Role of the SLC26 Transporters Family . Anion exchangers in flux: functional differences between human and mouse SLC26A6 polypeptides . Novartis Foundation Symposia . 273 . 107–19; discussion 119–25, 261–4 . 2007 . 17120764 . 10.1002/0470029579.ch8 . 9780470016244 .

Notes and References

1. Lohi H . Kujala M . Kerkela E . Saarialho-Kere U . Kestila M . Kere J . Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger . Genomics . 70 . 1 . 102–12 . Jan 2001 . 11087667 . 10.1006/geno.2000.6355 .
2. Waldegger S . Moschen I . Ramirez A . Smith RJ . Ayadi H . Lang F . Kubisch C . Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family . Genomics . 72 . 1 . 43–50 . Mar 2001 . 11247665 . 10.1006/geno.2000.6445 .
3. Web site: Entrez Gene: SLC26A6 solute carrier family 26, member 6.
4. Wang. Zhaohui. Tong Wang . Snezana Petrovic . Biguang Tuo . Brigitte Riederer . Sharon Barone . John N. Lorenz . Ursula Seidler . Peter S. Aronson . Manoocher Soleimani . Renal and intestinal transport defects in Slc26a6-null mice. American Journal of Physiology. Cell Physiology. April 2005. 288. 4. 4. C957–C965. 10.1152/ajpcell.00505.2004. 15574486. 23214608 .
5. Web site: SLC26A6 Gene - GeneCards S26A6 Protein S26A6 Antibody. 2021-05-06. www.genecards.org.