SLC25A39 explained

Solute carrier family 25 member 39 is a protein that in humans is encoded by the SLC25A39 gene.^{[1] [2]} The protein has been shown to be necessary for the import of the major antioxidant glutathione into the mitochondria. ^{[3] [4]}

Further reading

• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Simpson JC, Wellenreuther R, Poustka A, etal . Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. . EMBO Rep. . 1 . 3 . 287–92 . 2001 . 11256614 . 10.1093/embo-reports/kvd058 . 1083732 .
• Wiemann S, Weil B, Wellenreuther R, etal . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 .
• Yu XX, Lewin DA, Zhong A, etal . Overexpression of the human 2-oxoglutarate carrier lowers mitochondrial membrane potential in HEK-293 cells: contrast with the unique cold-induced mitochondrial carrier CGI-69. . Biochem. J. . 353 . Pt 2 . 369–75 . 2001 . 11139402 . 10.1042/0264-6021:3530369 . 1221580 .
• Lai CH, Chou CY, Ch'ang LY, etal . Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. . Genome Res. . 10 . 5 . 703–13 . 2000 . 10810093 . 10.1101/gr.10.5.703 . 310876 .

Notes and References

1. Haitina T, Lindblom J, Renstrom T, Fredriksson R . Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system . Genomics . 88 . 6 . 779–90 . Nov 2006 . 16949250 . 10.1016/j.ygeno.2006.06.016 . free .
2. Web site: Entrez Gene: SLC25A39 solute carrier family 25, member 39.
3. Wang Y, Yen FS, Zhu XG, Timson RC, Weber R, Xing C, Liu Y, Allwein B, Luo H, Yeh H, Heissel S, Unlu G, Gamazon ER, Kharas MG, Hite R, Birsoy K . SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells . Nature . 599 . 7883 . 136–140 . Nov 2021 . 34707288 . 10.1038/s41586-021-04025-w . 2021Natur.599..136W . 240072540 . 10981497 .
4. Web site: Scientists discover how mitochondria import antioxidants. January 22, 2022.