Mitochondrial thiamine pyrophosphate carrier explained

Mitochondrial thiamine pyrophosphate carrier is a protein that in humans is encoded by the SLC25A19 gene.^{[1] [2] [3]}

See also

• Solute carrier family

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Rosenberg MJ, Agarwala R, Bouffard G, etal . Mutant deoxynucleotide carrier is associated with congenital microcephaly . Nat. Genet. . 32 . 1 . 175–9 . 2002 . 12185364 . 10.1038/ng948 . 23768596 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Carrisi C, Antonucci D, etal . Transport of platinum bonded nucleotides into proteoliposomes, mediated by Drosophila melanogaster thiamine pyrophosphate carrier protein (DmTpc1). . Journal of Inorganic Biochemistry. 130 . 28–31 . 2013 . 24148759 . 10.1016/j.jinorgbio.2013.09.012.
• Lam W, Chen C, Ruan S, etal . Expression of deoxynucleotide carrier is not associated with the mitochondrial DNA depletion caused by anti-HIV dideoxynucleoside analogs and mitochondrial dNTP uptake . Mol. Pharmacol. . 67 . 2 . 408–16 . 2005 . 15539640 . 10.1124/mol.104.007120 . 25269301 .
• Otsuki T, Ota T, Nishikawa T, etal . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries . DNA Res. . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . free .
• Lindhurst MJ, Fiermonte G, Song S, etal . Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia . Proc. Natl. Acad. Sci. U.S.A. . 103 . 43 . 15927–32 . 2006 . 17035501 . 10.1073/pnas.0607661103 . 1595310 . 2006PNAS..10315927L . free .
• Iacopetta D, Carrisi C, et al. . The biochemical properties of the mitochondrial thiamine pyrophosphate carrier from Drosophila melanogaster. . FEBS J . 277 . 1172–81 . 2010 . 5 . 20121944 . 10.1111/j.1742-4658.2009.07550.x . 24140143 . free .

External links

• GeneReviews/NCBI/NIH/UW entry on Amish Lethal Microcephaly
• OMIM entries on Amish Lethal Microcephaly

Notes and References

1. Iacobazzi V, Ventura M, Fiermonte G, Prezioso G, Rocchi M, Palmieri F . Genomic organization and mapping of the gene (SLC25A19) encoding the human mitochondrial deoxynucleotide carrier (DNC) . Cytogenet Cell Genet . 93 . 1–2 . 40–2 . Jul 2001 . 11474176 . 10.1159/000056945 . 44985945 .
2. Dolce V, Fiermonte G, Runswick MJ, Palmieri F, Walker JE . The human mitochondrial deoxynucleotide carrier and its role in the toxicity of nucleoside antivirals . Proc Natl Acad Sci U S A . 98 . 5 . 2284–8 . Mar 2001 . 11226231 . 30130 . 10.1073/pnas.031430998 . 2001PNAS...98.2284D . free .
3. Web site: Entrez Gene: SLC25A19 solute carrier family 25 (mitochondrial deoxynucleotide carrier), member 19.