SLC23A2 explained

Solute carrier family 23 member 2 is a protein that in humans is encoded by the SLC23A2 gene.^{[1] [2] [3]}

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1.^[3]

See also

• Solute carrier family

Further reading

• Liang WJ, Johnson D, Jarvis SM . Vitamin C transport systems of mammalian cells. . Mol. Membr. Biol. . 18 . 1 . 87–95 . 2001 . 11396616 . 10.1080/09687680110033774 . 22478598 . free .
• Nakajima D, Okazaki N, Yamakawa H, etal . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. . DNA Res. . 9 . 3 . 99–106 . 2003 . 12168954 . 10.1093/dnares/9.3.99 . free .
• Nagase T, Seki N, Ishikawa K, etal . Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. . DNA Res. . 3 . 5 . 321–9, 341–54 . 1997 . 9039502 . 10.1093/dnares/3.5.321 . free .
• Hogue DL, Ling V . A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals. . Genomics . 59 . 1 . 18–23 . 1999 . 10395795 . 10.1006/geno.1999.5847 .
• Rajan DP, Huang W, Dutta B, etal . Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function. . Biochem. Biophys. Res. Commun. . 262 . 3 . 762–8 . 1999 . 10471399 . 10.1006/bbrc.1999.1272 .
• Daruwala R, Song J, Koh WS, etal . Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2. . FEBS Lett. . 460 . 3 . 480–4 . 1999 . 10556521 . 10.1016/S0014-5793(99)01393-9 . 37936975 . free .
• Breton S, Wiederhold T, Marshansky V, etal . The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells. . J. Biol. Chem. . 275 . 24 . 18219–24 . 2000 . 10748165 . 10.1074/jbc.M909857199 . free .
• Holliday LS, Lu M, Lee BS, etal . The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site. . J. Biol. Chem. . 275 . 41 . 32331–7 . 2000 . 10915794 . 10.1074/jbc.M004795200 . free .
• Deloukas P, Matthews LH, Ashurst J, etal . The DNA sequence and comparative analysis of human chromosome 20. . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . free .
• Hediger MA . New view at C. . Nat. Med. . 8 . 5 . 445–6 . 2002 . 11984580 . 10.1038/nm0502-445 . 787845 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Fischer H, Schwarzer C, Illek B . Vitamin C controls the cystic fibrosis transmembrane conductance regulator chloride channel. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 10 . 3691–6 . 2004 . 14993613 . 10.1073/pnas.0308393100 . 373524 . 2004PNAS..101.3691F . free .
• Lutsenko EA, Carcamo JM, Golde DW . A human sodium-dependent vitamin C transporter 2 isoform acts as a dominant-negative inhibitor of ascorbic acid transport. . Mol. Cell. Biol. . 24 . 8 . 3150–6 . 2004 . 15060139 . 10.1128/MCB.24.8.3150-3156.2004 . 381605 .
• Seno T, Inoue N, Matsui K, etal . Functional expression of sodium-dependent vitamin C transporter 2 in human endothelial cells. . J. Vasc. Res. . 41 . 4 . 345–51 . 2004 . 15340249 . 10.1159/000080525 . 20754421 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• McNulty AL, Vail TP, Kraus VB . Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2. . Biochim. Biophys. Acta . 1712 . 2 . 212–21 . 2005 . 15921655 . 10.1016/j.bbamem.2005.04.009 .

Notes and References

1. Faaland CA, Race JE, Ricken G, Warner FJ, Williams WJ, Holtzman EJ . Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters . Biochim Biophys Acta . 1442 . 2–3 . 353–60 . Dec 1998 . 9804989 . 10.1016/S0167-4781(98)00151-1.
2. Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA . A family of mammalian Na+-dependent L-ascorbic acid transporters . Nature . 399 . 6731 . 70–5 . Jun 1999 . 10331392 . 10.1038/19986 . 1999Natur.399...70T . 4425479 .
3. Web site: Entrez Gene: SLC23A2 solute carrier family 23 (nucleobase transporters), member 2.