SLC23A1 explained

Solute carrier family 23 member 1 is a protein that in humans is encoded by the SLC23A1 gene.^{[1] [2] [3]}

Function

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2.

See also

• Solute carrier family

Further reading

• Liang WJ, Johnson D, Jarvis SM . Vitamin C transport systems of mammalian cells . Molecular Membrane Biology . 18 . 1 . 87–95 . 2001 . 11396616 . 10.1080/09687680110033774 . 22478598 . free .
• Hogue DL, Ling V . A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals . Genomics . 59 . 1 . 18–23 . July 1999 . 10395795 . 10.1006/geno.1999.5847 .
• Rajan DP, Huang W, Dutta B, Devoe LD, Leibach FH, Ganapathy V, Prasad PD . Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function . Biochemical and Biophysical Research Communications . 262 . 3 . 762–8 . September 1999 . 10471399 . 10.1006/bbrc.1999.1272 .
• Wang H, Dutta B, Huang W, Devoe LD, Leibach FH, Ganapathy V, Prasad PD . Human Na(+)-dependent vitamin C transporter 1 (hSVCT1): primary structure, functional characteristics and evidence for a non-functional splice variant . Biochimica et Biophysica Acta (BBA) - Biomembranes . 1461 . 1 . 1–9 . November 1999 . 10556483 . 10.1016/S0005-2736(99)00182-0 .
• Daruwala R, Song J, Koh WS, Rumsey SC, Levine M . Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2 . FEBS Letters . 460 . 3 . 480–4 . November 1999 . 10556521 . 10.1016/S0014-5793(99)01393-9 . 37936975 . free .
• Wang Y, Mackenzie B, Tsukaguchi H, Weremowicz S, Morton CC, Hediger MA . Human vitamin C (L-ascorbic acid) transporter SVCT1 . Biochemical and Biophysical Research Communications . 267 . 2 . 488–94 . January 2000 . 10631088 . 10.1006/bbrc.1999.1929 .
• Erichsen HC, Eck P, Levine M, Chanock S . Characterization of the genomic structure of the human vitamin C transporter SVCT1 (SLC23A2) . The Journal of Nutrition . 131 . 10 . 2623–7 . October 2001 . 11584081 . 10.1093/jn/131.10.2623. free .
• Hediger MA . New view at C . Nature Medicine . 8 . 5 . 445–6 . May 2002 . 11984580 . 10.1038/nm0502-445 . 787845 .
• Maulén NP, Henríquez EA, Kempe S, Cárcamo JG, Schmid-Kotsas A, Bachem M, Grünert A, Bustamante ME, Nualart F, Vera JC . Up-regulation and polarized expression of the sodium-ascorbic acid transporter SVCT1 in post-confluent differentiated CaCo-2 cells . The Journal of Biological Chemistry . 278 . 11 . 9035–41 . March 2003 . 12381735 . 10.1074/jbc.M205119200 . free .
• Liang WJ, Johnson D, Ma LS, Jarvis SM, Wei-Jun L . Regulation of the human vitamin C transporters expressed in COS-1 cells by protein kinase C [corrected] . American Journal of Physiology. Cell Physiology . 283 . 6 . C1696-704 . December 2002 . 12388072 . 10.1152/ajpcell.00461.2001 .
• Boyer JC, Campbell CE, Sigurdson WJ, Kuo SM . Polarized localization of vitamin C transporters, SVCT1 and SVCT2, in epithelial cells . Biochemical and Biophysical Research Communications . 334 . 1 . 150–6 . August 2005 . 15993839 . 10.1016/j.bbrc.2005.06.069 .
• Erichsen HC, Engel SA, Eck PK, Welch R, Yeager M, Levine M, Siega-Riz AM, Olshan AF, Chanock SJ . Genetic variation in the sodium-dependent vitamin C transporters, SLC23A1, and SLC23A2 and risk for preterm delivery . American Journal of Epidemiology . 163 . 3 . 245–54 . February 2006 . 16357110 . 10.1093/aje/kwj035 . free .
• Kang JS, Kim HN, Jung DJ, Kim JE, Mun GH, Kim YS, Cho D, Shin DH, Hwang YI, Lee WJ . Regulation of UVB-induced IL-8 and MCP-1 production in skin keratinocytes by increasing vitamin C uptake via the redistribution of SVCT-1 from the cytosol to the membrane . The Journal of Investigative Dermatology . 127 . 3 . 698–706 . March 2007 . 17008880 . 10.1038/sj.jid.5700572 . free .

Notes and References

1. Faaland CA, Race JE, Ricken G, Warner FJ, Williams WJ, Holtzman EJ . Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1442 . 2–3 . 353–60 . November 1998 . 9804989 . 10.1016/S0167-4781(98)00151-1 .
2. Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA . A family of mammalian Na+-dependent L-ascorbic acid transporters . Nature . 399 . 6731 . 70–5 . May 1999 . 10331392 . 10.1038/19986 . 1999Natur.399...70T . 4425479 .
3. Web site: Entrez Gene: SLC23A1 solute carrier family 23 (nucleobase transporters), member 1.