SLC22A2 explained

Solute carrier family 22 member 2 (also termed OCT2 or organic cation transporter-2^[1]) is a protein that in humans is encoded by the SLC22A2 gene.^{[2] [3]}

Poly specific organic cation transporters in the liver, kidney, intestine, and other organs are important for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.^[3]

See also

• Solute carrier family

Further reading

• Berkhout B, Jeang KT . Functional roles for the TATA promoter and enhancers in basal and Tat-induced expression of the human immunodeficiency virus type 1 long terminal repeat. . J. Virol. . 66 . 1 . 139–49 . 1992 . 1727476 . 10.1128/JVI.66.1.139-149.1992. 238269 .
• Jeang KT, Chun R, Lin NH, etal . In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor. . J. Virol. . 67 . 10 . 6224–33 . 1993 . 7690421 . 10.1128/JVI.67.10.6224-6233.1993. 238044 .
• Liu YZ, Lania L, Latchman DS . Functional interaction between the HIV-1 Tat transactivator and the inhibitory domain of the Oct-2 cellular transcription factor. . AIDS . 10 . 12 . 1323–9 . 1997 . 8902060 . 10.1097/00002030-199610000-00003 . 11659500 .
• Liu YZ, Latchman DS . The octamer-binding proteins Oct-1 and Oct-2 repress the HIV long terminal repeat promoter and its transactivation by Tat. . Biochem. J. . 322 . 1. 155–8 . 1997 . 9078256 . 10.1042/bj3220155. 1218171 .
• Gorboulev V, Ulzheimer JC, Akhoundova A, etal . Cloning and characterization of two human polyspecific organic cation transporters. . DNA Cell Biol. . 16 . 7 . 871–81 . 1997 . 9260930 . 10.1089/dna.1997.16.871 .
• Busch AE, Karbach U, Miska D, etal . Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. . Mol. Pharmacol. . 54 . 2 . 342–52 . 1998 . 9687576 . 10.1124/mol.54.2.342.
• Verhaagh S, Schweifer N, Barlow DP, Zwart R . Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27. . Genomics . 55 . 2 . 209–18 . 1999 . 9933568 . 10.1006/geno.1998.5639 .
• Gründemann D, Schömig E . Gene structures of the human non-neuronal monoamine transporters EMT and OCT2. . Hum. Genet. . 106 . 6 . 627–35 . 2000 . 10942111 . 10.1007/s004390050035 .
• Pietig G, Mehrens T, Hirsch JR, etal . Properties and regulation of organic cation transport in freshly isolated human proximal tubules. . J. Biol. Chem. . 276 . 36 . 33741–6 . 2001 . 11447227 . 10.1074/jbc.M104617200 . free .
• Boehm J, He Y, Greiner A, etal . Regulation of BOB.1/OBF.1 stability by SIAH. . EMBO J. . 20 . 15 . 4153–62 . 2001 . 11483518 . 10.1093/emboj/20.15.4153 . 149152 .
• Barendt WM, Wright SH . The human organic cation transporter (hOCT2) recognizes the degree of substrate ionization. . J. Biol. Chem. . 277 . 25 . 22491–6 . 2002 . 11953440 . 10.1074/jbc.M203114200 . free .
• Urakami Y, Akazawa M, Saito H, etal . cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. . J. Am. Soc. Nephrol. . 13 . 7 . 1703–10 . 2002 . 12089365 . 10.1097/01.ASN.0000019413.78751.46 . free .
• Leabman MK, Huang CC, Kawamoto M, etal . Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function. . Pharmacogenetics . 12 . 5 . 395–405 . 2003 . 12142729 . 10.1097/00008571-200207000-00007 .
• Cetinkaya I, Ciarimboli G, Yalçinkaya G, etal . Regulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinases. . Am. J. Physiol. Renal Physiol. . 284 . 2 . F293–302 . 2003 . 12388397 . 10.1152/ajprenal.00251.2002 . 38608510 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gründemann D, Hahne C, Berkels R, Schömig E . Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2). . J. Pharmacol. Exp. Ther. . 304 . 2 . 810–7 . 2003 . 12538837 . 10.1124/jpet.102.044404 . 11496882 .
• Bottalico B, Larsson I, Brodszki J, etal . Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies. . Placenta . 25 . 6 . 518–29 . 2004 . 15135235 . 10.1016/j.placenta.2003.10.017 .
• Lips KS, Volk C, Schmitt BM, etal . Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium. . Am. J. Respir. Cell Mol. Biol. . 33 . 1 . 79–88 . 2005 . 15817714 . 10.1165/rcmb.2004-0363OC . 10.1.1.327.6767 .
• Jiang W, Prokopenko O, Wong L, etal . IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity. . Mol. Cell. Biol. . 25 . 15 . 6496–508 . 2005 . 16024787 . 10.1128/MCB.25.15.6496-6508.2005 . 1190334 .

Notes and References

1. Web site: SLC22A2 solute carrier family 22 member 2 [Homo sapiens (human)] - Gene - NCBI.
2. Koehler MR, Wissinger B, Gorboulev V, Koepsell H, Schmid M . The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26 . Cytogenet Cell Genet . 79 . 3–4 . 198–200 . Jun 1998 . 9605850 . 10.1159/000134720 .
3. Web site: Entrez Gene: SLC22A2 solute carrier family 22 (organic cation transporter), member 2.