SLC22A13 explained
Solute carrier family 22 member 13 is a protein that in humans is encoded by the SLC22A13 gene.[1]
Function
This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 4. The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein can function to mediate urate uptake and is a high affinity nicotinate exchanger in the kidneys and the intestine.
Further reading
- Bahn A, Hagos Y, Reuter S, Balen D, Brzica H, Krick W, Burckhardt BC, Sabolic I, Burckhardt G . Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13) . J. Biol. Chem. . 283 . 24 . 16332–41 . 2008 . 18411268 . 10.1074/jbc.M800737200 . free .
- Irshad S, Mahul-Mellier AL, Kassouf N, Lemarie A, Grimm S . Isolation of ORCTL3 in a novel genetic screen for tumor-specific apoptosis inducers . Cell Death Differ. . 16 . 6 . 890–8 . 2009 . 19282870 . 2683172 . 10.1038/cdd.2009.21 .
- Tzvetkov MV, Vormfelde SV, Balen D, Meineke I, Schmidt T, Sehrt D, Sabolić I, Koepsell H, Brockmöller J . The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin . Clin. Pharmacol. Ther. . 86 . 3 . 299–306 . 2009 . 19536068 . 10.1038/clpt.2009.92 . 8583867 .
- Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score . Mol. Med. . 16 . 7–8 . 247–53 . 2010 . 20379614 . 2896464 . 10.2119/molmed.2009.00159 .
- Schulz C, Fork C, Bauer T, Golz S, Geerts A, Schömig E, Gründemann D . SLC22A13 catalyses unidirectional efflux of aspartate and glutamate at the basolateral membrane of type A intercalated cells in the renal collecting duct . Biochem. J. . 457 . 2 . 243–51 . 2014 . 24147638 . 10.1042/BJ20130654 .
- AbuAli G, Chaisaklert W, Stelloo E, Pazarentzos E, Hwang MS, Qize D, Harding SV, Al-Rubaish A, Alzahrani AJ, Al-Ali A, Sanders TA, Aboagye EO, Grimm S . The anticancer gene ORCTL3 targets stearoyl-CoA desaturase-1 for tumour-specific apoptosis . Oncogene . 34 . 13 . 1718–28 . 2015 . 24769897 . 4119473 . 10.1038/onc.2014.93 .
Notes and References
- Web site: Entrez Gene: Solute carrier family 22 member 13. 2017-10-05.
