SLC20A1 explained

Sodium-dependent phosphate transporter 1 is a protein that in humans is encoded by the SLC20A1 gene.^{[1] [2]}

Retrovirus receptors allow infection of human and murine cells by various retroviruses. The receptors that have been identified at the molecular level include CD4 (MIM 186940) for human immunodeficiency virus, Rec1 for murine ecotropic virus, and GLVR1 for gibbon ape leukemia virus (see MIM 182090). These 3 proteins show no homology to one another at the DNA or protein level. GLVR1 is a sodium-dependent phosphate symporter.[supplied by OMIM]

Research

It was reported that mutations of the gene may cause epispadias or bladder exstrophy.^[3]

See also

• Solute carrier family

Further reading

• Takeuchi Y, Vile RG, Simpson G, etal . Feline leukemia virus subgroup B uses the same cell surface receptor as gibbon ape leukemia virus. . J. Virol. . 66 . 2 . 1219–22 . 1992 . 1309898 . 10.1128/JVI.66.2.1219-1222.1992. 240831 .
• Johann SV, Gibbons JJ, O'Hara B . GLVR1, a receptor for gibbon ape leukemia virus, is homologous to a phosphate permease of Neurospora crassa and is expressed at high levels in the brain and thymus. . J. Virol. . 66 . 3 . 1635–40 . 1992 . 1531369 . 10.1128/JVI.66.3.1635-1640.1992. 240899 .
• Kaelbling M, Eddy R, Shows TB, etal . Localization of the human gene allowing infection by gibbon ape leukemia virus to human chromosome region 2q11-q14 and to the homologous region on mouse chromosome 2. . J. Virol. . 65 . 4 . 1743–7 . 1991 . 1672162 . 10.1128/JVI.65.4.1743-1747.1991. 239979 .
• O'Hara B, Johann SV, Klinger HP, etal . Characterization of a human gene conferring sensitivity to infection by gibbon ape leukemia virus. . Cell Growth Differ. . 1 . 3 . 119–27 . 1991 . 2078500 .
• Olah Z, Lehel C, Anderson WB, etal . The cellular receptor for gibbon ape leukemia virus is a novel high affinity sodium-dependent phosphate transporter. . J. Biol. Chem. . 269 . 41 . 25426–31 . 1994 . 10.1016/S0021-9258(18)47267-5 . 7929240 . free .
• Miller DG, Miller AD . A family of retroviruses that utilize related phosphate transporters for cell entry. . J. Virol. . 68 . 12 . 8270–6 . 1994 . 7966619 . 10.1128/JVI.68.12.8270-8276.1994. 237294 .
• Johann SV, van Zeijl M, Cekleniak J, O'Hara B . Definition of a domain of GLVR1 which is necessary for infection by gibbon ape leukemia virus and which is highly polymorphic between species. . J. Virol. . 67 . 11 . 6733–6 . 1993 . 8411375 . 10.1128/JVI.67.11.6733-6736.1993. 238113 .
• Tatsumi S, Segawa H, Morita K, etal . Molecular cloning and hormonal regulation of PiT-1, a sodium-dependent phosphate cotransporter from rat parathyroid glands. . Endocrinology . 139 . 4 . 1692–9 . 1998 . 9528951 . 10.1210/endo.139.4.5925 . free .
• Palmer G, Manen D, Bonjour JP, Caverzasio J . Characterization of the human Glvr-1 phosphate transporter/retrovirus receptor gene and promoter region. . Gene . 226 . 1 . 25–33 . 1999 . 9889306 . 10.1016/S0378-1119(98)00572-1 .
• Jono S, McKee MD, Murry CE, etal . Phosphate regulation of vascular smooth muscle cell calcification. . Circ. Res. . 87 . 7 . E10–7 . 2000 . 11009570 . 10.1161/01.RES.87.7.e10 . free .
• Farrell KB, Russ JL, Murthy RK, Eiden MV . Reassessing the role of region A in Pit1-mediated viral entry. . J. Virol. . 76 . 15 . 7683–93 . 2002 . 12097582 . 10.1128/JVI.76.15.7683-7693.2002 . 136385 .
• Bottger P, Pedersen L . Two highly conserved glutamate residues critical for type III sodium-dependent phosphate transport revealed by uncoupling transport function from retroviral receptor function. . J. Biol. Chem. . 277 . 45 . 42741–7 . 2003 . 12205090 . 10.1074/jbc.M207096200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Matsuda A, Suzuki Y, Honda G, etal . Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. . Oncogene . 22 . 21 . 3307–18 . 2003 . 12761501 . 10.1038/sj.onc.1206406 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Cecil DL, Rose DM, Terkeltaub R, Liu-Bryan R . Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes. . Arthritis Rheum. . 52 . 1 . 144–54 . 2005 . 15641067 . 10.1002/art.20748 . free .
• Hillier LW, Graves TA, Fulton RS, etal . Generation and annotation of the DNA sequences of human chromosomes 2 and 4. . Nature . 434 . 7034 . 724–31 . 2005 . 15815621 . 10.1038/nature03466 . 2005Natur.434..724H . free .
• Li X, Yang HY, Giachelli CM . Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification. . Circ. Res. . 98 . 7 . 905–12 . 2006 . 16527991 . 10.1161/01.RES.0000216409.20863.e7 . free .
• Bøttger P, Hede SE, Grunnet M, etal . Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2. . Am. J. Physiol., Cell Physiol. . 291 . 6 . C1377–87 . 2007 . 16790504 . 10.1152/ajpcell.00015.2006 .

Notes and References

1. Kavanaugh MP, Miller DG, Zhang W, Law W, Kozak SL, Kabat D, Miller AD . Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters . Proc Natl Acad Sci U S A . 91 . 15 . 7071–5 . Aug 1994 . 8041748 . 44340 . 10.1073/pnas.91.15.7071 . 1994PNAS...91.7071K . free .
2. Web site: Entrez Gene: SLC20A1 solute carrier family 20 (phosphate transporter), member 1.
3. Rieke JM, Zhang R, Braun D, Yilmaz Ö, Japp AS, Lopes FM, etal . SLC20A1 Is Involved in Urinary Tract and Urorectal Development. Frontiers in Cell and Developmental Biology. 8. 2020 . 567. 10.3389/fcell.2020.00567. 32850778. 7426641. free.