Neutral amino acid transporter B(0) explained

Neutral amino acid transporter B(0) is a protein that in humans is encoded by the SLC1A5 gene.^{[1] [2] [3]}

See also

• Glutamate transporter
• Solute carrier family

Further reading

• Tailor CS, Nouri A, Zhao Y, Takeuchi Y, Kabat D . A sodium-dependent neutral-amino-acid transporter mediates infections of feline and baboon endogenous retroviruses and simian type D retroviruses . Journal of Virology . 73 . 5 . 4470–4 . May 1999 . 10196349 . 104338 . 10.1128/JVI.73.5.4470-4474.1999.
• Tailor CS, Marin M, Nouri A, Kavanaugh MP, Kabat D . Truncated forms of the dual function human ASCT2 neutral amino acid transporter/retroviral receptor are translationally initiated at multiple alternative CUG and GUG codons . The Journal of Biological Chemistry . 276 . 29 . 27221–30 . July 2001 . 11350958 . 10.1074/jbc.M100737200 . free .
• Lavillette D, Marin M, Ruggieri A, Mallet F, Cosset FL, Kabat D . The envelope glycoprotein of human endogenous retrovirus type W uses a divergent family of amino acid transporters/cell surface receptors . Journal of Virology . 76 . 13 . 6442–52 . July 2002 . 12050356 . 136247 . 10.1128/JVI.76.13.6442-6452.2002 .
• Kudo Y, Boyd CA . Changes in expression and function of syncytin and its receptor, amino acid transport system B(0) (ASCT2), in human placental choriocarcinoma BeWo cells during syncytialization . Placenta . 23 . 7 . 536–41 . August 2002 . 12175968 . 10.1053/plac.2002.0839 .
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proceedings of the National Academy of Sciences of the United States of America . 99 . 26 . 16899–903 . December 2002 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . free .
• Potter SJ, Lu A, Wilcken B, Green K, Rasko JE . Hartnup disorder: polymorphisms identified in the neutral amino acid transporter SLC1A5 . Journal of Inherited Metabolic Disease . 25 . 6 . 437–48 . October 2002 . 12555937 . 10.1023/A:1021286714582 . 21082701 .
• Marin M, Lavillette D, Kelly SM, Kabat D . N-linked glycosylation and sequence changes in a critical negative control region of the ASCT1 and ASCT2 neutral amino acid transporters determine their retroviral receptor functions . Journal of Virology . 77 . 5 . 2936–45 . March 2003 . 12584318 . 149750 . 10.1128/JVI.77.5.2936-2945.2003 .
• Kudo Y, Boyd CA, Sargent IL, Redman CW . Hypoxia alters expression and function of syncytin and its receptor during trophoblast cell fusion of human placental BeWo cells: implications for impaired trophoblast syncytialisation in pre-eclampsia . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease . 1638 . 1 . 63–71 . May 2003 . 12757936 . 10.1016/s0925-4439(03)00043-7 .
• Knerr I, Weigel C, Linnemann K, Dötsch J, Meissner U, Fusch C, Rascher W . Transcriptional effects of hypoxia on fusiogenic syncytin and its receptor ASCT2 in human cytotrophoblast BeWo cells and in ex vivo perfused placental cotyledons . American Journal of Obstetrics and Gynecology . 189 . 2 . 583–8 . August 2003 . 14520239 . 10.1067/S0002-9378(03)00538-6 .
• Palmada M, Speil A, Jeyaraj S, Böhmer C, Lang F . The serine/threonine kinases SGK1, 3 and PKB stimulate the amino acid transporter ASCT2 . Biochemical and Biophysical Research Communications . 331 . 1 . 272–7 . May 2005 . 15845389 . 10.1016/j.bbrc.2005.03.159 .
• Uchiyama T, Matsuda Y, Wada M, Takahashi S, Fujita T . Functional regulation of Na+-dependent neutral amino acid transporter ASCT2 by S-nitrosothiols and nitric oxide in Caco-2 cells . FEBS Letters . 579 . 11 . 2499–506 . April 2005 . 15848195 . 10.1016/j.febslet.2005.03.065 . 23438613 . free .
• Bungard CI, McGivan JD . Identification of the promoter elements involved in the stimulation of ASCT2 expression by glutamine availability in HepG2 cells and the probable involvement of FXR/RXR dimers . Archives of Biochemistry and Biophysics . 443 . 1–2 . 53–9 . November 2005 . 16197915 . 10.1016/j.abb.2005.08.016 .
• Brauers E, Vester U, Zerres K, Eggermann T . Search for mutations in SLC1A5 (19q13) in cystinuria patients . Journal of Inherited Metabolic Disease . 28 . 6 . 1169–71 . 2006 . 16435221 . 10.1007/s10545-005-0094-x . 29372429 .
• Gegelashvili M, Rodriguez-Kern A, Pirozhkova I, Zhang J, Sung L, Gegelashvili G . High-affinity glutamate transporter GLAST/EAAT1 regulates cell surface expression of glutamine/neutral amino acid transporter ASCT2 in human fetal astrocytes . Neurochemistry International . 48 . 6–7 . 611–5 . 2006 . 16516348 . 10.1016/j.neuint.2005.12.033 . 20686585 .
• Cheynet V, Oriol G, Mallet F . Identification of the hASCT2-binding domain of the Env ERVWE1/syncytin-1 fusogenic glycoprotein . Retrovirology . 3 . 41 . July 2006 . 16820059 . 1524976 . 10.1186/1742-4690-3-41 . free .
• Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, Huang H, Canfield VA, Cheng KC, Yang F, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E, Hunt DF . Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes . Journal of Proteome Research . 5 . 11 . 3135–44 . November 2006 . 17081065 . 10.1021/pr060363j .

Notes and References

1. Kekuda R, Prasad PD, Fei YJ, Torres-Zamorano V, Sinha S, Yang-Feng TL, Leibach FH, Ganapathy V . Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line . The Journal of Biological Chemistry . 271 . 31 . 18657–61 . August 1996 . 8702519 . 10.1074/jbc.271.31.18657 . free.
2. Rasko JE, Battini JL, Gottschalk RJ, Mazo I, Miller AD . The RD114/simian type D retrovirus receptor is a neutral amino acid transporter . Proceedings of the National Academy of Sciences of the United States of America . 96 . 5 . 2129–34 . March 1999 . 10051606 . 26748 . 10.1073/pnas.96.5.2129 . 1999PNAS...96.2129R . free .
3. Web site: Entrez Gene: SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5.