SLC17A3 explained

Solute carrier family 17 (organic anion transporter), member 3 is a protein that in humans is encoded by the SLC17A3 gene.^[1]

Function

The protein encoded by this gene is a voltage-driven transporter that excretes intracellular urate and organic anions from the blood into renal tubule cells. Two transcript variants encoding different isoforms have been found for this gene. The longer isoform is a plasma membrane protein with transporter activity while the shorter isoform localizes to the endoplasmic reticulum.^[1]

See also

• Glycogen storage disease type I

Further reading

• Polasek O, Jeroncić I, Mulić R, Klismanic Z, Pehlić M, Zemunik T, Kolcić I . Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series . Croat. Med. J. . 51 . 1 . 32–9 . 2010 . 20162743 . 2829186 . 10.3325/cmj.2010.51.32.
• Dehghan A, Köttgen A, Yang Q, Hwang SJ, Kao WL, Rivadeneira F, Boerwinkle E, Levy D, Hofman A, Astor BC, Benjamin EJ, van Duijn CM, Witteman JC, Coresh J, Fox CS . Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study . Lancet . 372 . 9654 . 1953–61 . 2008 . 18834626 . 2803340 . 10.1016/S0140-6736(08)61343-4 .
• Ruddy DA, Kronmal GS, Lee VK, Mintier GA, Quintana L, Domingo R, Meyer NC, Irrinki A, McClelland EE, Fullan A, Mapa FA, Moore T, Thomas W, Loeb DB, Harmon C, Tsuchihashi Z, Wolff RK, Schatzman RC, Feder JN . A 1.1-Mb transcript map of the hereditary hemochromatosis locus . Genome Res. . 7 . 5 . 441–56 . 1997 . 9149941 . 10.1101/gr.7.5.441. free .
• Jutabha P, Anzai N, Kitamura K, Taniguchi A, Kaneko S, Yan K, Yamada H, Shimada H, Kimura T, Katada T, Fukutomi T, Tomita K, Urano W, Yamanaka H, Seki G, Fujita T, Moriyama Y, Yamada A, Uchida S, Wempe MF, Endou H, Sakurai H . Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate . J. Biol. Chem. . 285 . 45 . 35123–32 . 2010 . 20810651 . 2966126 . 10.1074/jbc.M110.121301 . free .
• Stark K, Reinhard W, Grassl M, Erdmann J, Schunkert H, Illig T, Hengstenberg C . Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease . PLOS ONE . 4 . 11 . e7729 . 2009 . 19890391 . 2766838 . 10.1371/journal.pone.0007729 . 2009PLoSO...4.7729S . free .
• Jutabha P, Anzai N, Kimura T, Taniguchi A, Urano W, Yamanaka H, Endou H, Sakurai H . Functional analysis of human sodium-phosphate transporter 4 (NPT4/SLC17A3) polymorphisms . J. Pharmacol. Sci. . 115 . 2 . 249–53 . 2011 . 21282933 . 10.1254/jphs.10228sc. free .
• Melis D, Havelaar AC, Verbeek E, Smit GP, Benedetti A, Mancini GM, Verheijen F . NPT4, a new microsomal phosphate transporter: mutation analysis in glycogen storage disease type Ic . J. Inherit. Metab. Dis. . 27 . 6 . 725–33 . 2004 . 15505377 . 10.1023/B:BOLI.0000045755.89308.2f . 20942710 .

Notes and References

1. Web site: Entrez Gene: Solute carrier family 17 (organic anion transporter), member 3 .