Urea transporter 1 explained

Urea transporter 1 is a protein that in humans is encoded by the SLC14A1 gene.^{[1] [2]}

Function

The SLC14A1 codes for a urea transporter (UTB) that is expressed in erythrocytes and kidney. SLC14A2 and SLC14A1 constitute solute carrier family 14. UTB proteins constitute the Kidd antigen system.

Further reading

• Geitvik GA, Høyheim B, Gedde-Dahl T, etal . The Kidd (JK) blood group locus assigned to chromosome 18 by close linkage to a DNA-RFLP. . Hum. Genet. . 77 . 3 . 205–9 . 1987 . 2890568 . 10.1007/BF00284470 . 23739401 .
• Olives B, Neau P, Bailly P, etal . Cloning and functional expression of a urea transporter from human bone marrow cells. . J. Biol. Chem. . 269 . 50 . 31649–52 . 1995 . 10.1016/S0021-9258(18)31744-7 . 7989337 . free .
• Davey S, Beach D . RACH2, a novel human gene that complements a fission yeast cell cycle checkpoint mutation. . Mol. Biol. Cell . 6 . 10 . 1411–21 . 1996 . 8573795 . 10.1091/mbc.6.10.1411. 301296 .
• Olivès B, Martial S, Mattei MG, etal . Molecular characterization of a new urea transporter in the human kidney. . FEBS Lett. . 386 . 2–3 . 156–60 . 1996 . 8647271 . 10.1016/0014-5793(96)00425-5 . 13312002 .
• Olivès B, Merriman M, Bailly P, etal . The molecular basis of the Kidd blood group polymorphism and its lack of association with type 1 diabetes susceptibility. . Hum. Mol. Genet. . 6 . 7 . 1017–20 . 1997 . 9215669 . 10.1093/hmg/6.7.1017 . free .
• Lucien N, Sidoux-Walter F, Olivès B, etal . Characterization of the gene encoding the human Kidd blood group/urea transporter protein. Evidence for splice site mutations in Jknull individuals. . J. Biol. Chem. . 273 . 21 . 12973–80 . 1998 . 9582331 . 10.1074/jbc.273.21.12973 . free .
• Irshaid NM, Thuresson B, Olsson ML . Genomic typing of the Kidd blood group locus by a single-tube allele-specific primer PCR technique. . Br. J. Haematol. . 102 . 4 . 1010–4 . 1998 . 9734652 . 10.1046/j.1365-2141.1998.00874.x . 19082798 . free .
• Sidoux-Walter F, Lucien N, Olivès B, etal . At physiological expression levels the Kidd blood group/urea transporter protein is not a water channel. . J. Biol. Chem. . 274 . 42 . 30228–35 . 1999 . 10514515 . 10.1074/jbc.274.42.30228 . free . 2066/185970 . free .
• Irshaid NM, Henry SM, Olsson ML . Genomic characterization of the kidd blood group gene:different molecular basis of the Jk(a-b-) phenotype in Polynesians and Finns. . Transfusion . 40 . 1 . 69–74 . 2000 . 10644814 . 10.1046/j.1537-2995.2000.40010069.x . 43843439 .
• Sidoux-Walter F, Lucien N, Nissinen R, etal . Molecular heterogeneity of the Jk(null) phenotype: expression analysis of the Jk(S291P) mutation found in Finns. . Blood . 96 . 4 . 1566–73 . 2000 . 10942407 . 10.1182/blood.V96.4.1566. free .
• Lucien N, Chiaroni J, Cartron JP, Bailly P . Partial deletion in the JK locus causing a Jk(null) phenotype. . Blood . 99 . 3 . 1079–81 . 2002 . 11807016 . 10.1182/blood.V99.3.1079 . free .
• Irshaid NM, Eicher NI, Hustinx H, etal . Novel alleles at the JK blood group locus explain the absence of the erythrocyte urea transporter in European families. . Br. J. Haematol. . 116 . 2 . 445–53 . 2002 . 11841450 . 10.1046/j.1365-2141.2002.03238.x . 25830269 . free .
• Lucien N, Sidoux-Walter F, Roudier N, etal . Antigenic and functional properties of the human red blood cell urea transporter hUT-B1. . J. Biol. Chem. . 277 . 37 . 34101–8 . 2002 . 12093813 . 10.1074/jbc.M205073200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Inoue H, Jackson SD, Vikulina T, etal . Identification and characterization of a Kidd antigen/UT-B urea transporter expressed in human colon. . Am. J. Physiol., Cell Physiol. . 287 . 1 . C30–5 . 2004 . 14985236 . 10.1152/ajpcell.00443.2003 . 25576221 .

Notes and References

1. Olives B, Mattei MG, Huet M, Neau P, Martial S, Cartron JP, Bailly P . Kidd blood group and urea transport function of human erythrocytes are carried by the same protein . J Biol Chem . 270 . 26 . 15607–10 . Aug 1995 . 7797558 . 10.1074/jbc.270.26.15607 . free .
2. Web site: Entrez Gene: SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group).