SLC13A3 explained

Solute carrier family 13 member 3 also called sodium-dependent dicarboxylate transporter (NaDC3) is a protein that in humans is encoded by the SLC13A3 gene.^{[1] [2] [3]}

Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet.^[3]

See also

• Solute carrier family

Further reading

• Markovich D, Murer H . The SLC13 gene family of sodium sulphate/carboxylate cotransporters. . Pflügers Arch. . 447 . 5 . 594–602 . 2004 . 12915942 . 10.1007/s00424-003-1128-6 . 7609066 .
• Deloukas P, Matthews LH, Ashurst J, etal . The DNA sequence and comparative analysis of human chromosome 20. . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Burckhardt BC, Lorenz J, Kobbe C, Burckhardt G . Substrate specificity of the human renal sodium dicarboxylate cotransporter, hNaDC-3, under voltage-clamp conditions. . Am. J. Physiol. Renal Physiol. . 288 . 4 . F792–9 . 2005 . 15561973 . 10.1152/ajprenal.00360.2004 .
• Bai X, Chen X, Feng Z, etal . Identification of basolateral membrane targeting signal of human sodium-dependent dicarboxylate transporter 3. . J. Cell. Physiol. . 206 . 3 . 821–30 . 2006 . 16331647 . 10.1002/jcp.20553 . 37471691 . free .

Notes and References

1. Wang H, Fei YJ, Kekuda R, Yang-Feng TL, Devoe LD, Leibach FH, Prasad PD, Ganapathy V . Structure, function, and genomic organization of human Na(+)-dependent high-affinity dicarboxylate transporter . Am J Physiol Cell Physiol . 278 . 5 . C1019–30 . Jun 2000 . 10794676 . 10.1152/ajpcell.2000.278.5.C1019. 39532742 .
2. Huang W, Wang H, Kekuda R, Fei YJ, Friedrich A, Wang J, Conway SJ, Cameron RS, Leibach FH, Ganapathy V . Transport of N-acetylaspartate by the Na(+)-dependent high-affinity dicarboxylate transporter NaDC3 and its relevance to the expression of the transporter in the brain . J Pharmacol Exp Ther . 295 . 1 . 392–403 . Nov 2000 . 10992006 .
3. Web site: Entrez Gene: SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3.