Chloride potassium symporter 4 explained

Potassium-chloride transporter, member 4 is a chloride potassium symporter protein. It is encoded by the gene SLC12A4.^[1]

See also

• Solute carrier family

Further reading

• Larsen F, Solheim J, Kristensen T . A tight cluster of five unrelated human genes on chromosome 16q22.1. . Hum. Mol. Genet. . 2 . 10 . 1589–95 . 1994 . 8268911 . 10.1093/hmg/2.10.1589 . etal.
• Gillen CM, Brill S, Payne JA, Forbush B . Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family. . J. Biol. Chem. . 271 . 27 . 16237–44 . 1996 . 8663127 . 10.1074/jbc.271.27.16237 . free .
• Pellegrino CM, Rybicki AC, Musto S . Molecular identification and expression of erythroid K:Cl cotransporter in human and mouse erythroleukemic cells. . Blood Cells Mol. Dis. . 24 . 1 . 31–40 . 1998 . 9516379 . 10.1006/bcmd.1998.0168 . etal.
• Su W, Shmukler BE, Chernova MN . Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation. . Am. J. Physiol. . 277 . 5 Pt 1 . C899–912 . 1999 . 10564083 . 10.1152/ajpcell.1999.277.5.C899. etal.
• Casula S, Shmukler BE, Wilhelm S . A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity. . J. Biol. Chem. . 276 . 45 . 41870–8 . 2001 . 11551954 . 10.1074/jbc.M107155200 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Bräuer M, Frei E, Claes L . Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl⁻ channels in human osteoblasts . Am. J. Physiol., Cell Physiol. . 285 . 1 . C22–30 . 2003 . 12637262 . 10.1152/ajpcell.00289.2002 . etal.
• Shen MR, Chou CY, Hsu KF . KCl cotransport is an important modulator of human cervical cancer growth and invasion . J. Biol. Chem. . 278 . 41 . 39941–50 . 2003 . 12902337 . 10.1074/jbc.M308232200 . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Zhou GP, Wong C, Su R . Human potassium chloride cotransporter 1 (SLC12A4) promoter is regulated by AP-2 and contains a functional downstream promoter element . Blood . 103 . 11 . 4302–9 . 2004 . 14976052 . 10.1182/blood-2003-01-0107 . etal. free .
• Khan AI, Drew C, Ball SE . Oxygen dependence of K⁺–Cl⁻ cotransport in human red cell ghosts and sickle cells . Bioelectrochemistry. 62 . 2 . 141–6 . 2005 . 15039017 . 10.1016/j.bioelechem.2003.07.005 . etal.
• Colland F, Jacq X, Trouplin V . Functional Proteomics Mapping of a Human Signaling Pathway . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 . etal.
• Shen MR, Lin AC, Hsu YM . Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells . J. Biol. Chem. . 279 . 38 . 40017–25 . 2004 . 15262997 . 10.1074/jbc.M406706200 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.

Notes and References

1. Web site: Entrez Gene: SLC12A4 solute carrier family 12 (potassium/chloride transporters), member 4.