Natural resistance-associated macrophage protein 1 explained

Natural resistance-associated macrophage protein 1 is a protein that in humans is encoded by the SLC11A1 gene.^{[1] [2] [3]}

Function

This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn's disease.^[4] Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.

See also

• Solute carrier family

Further reading

• Blackwell JM, Searle S, Mohamed H, White JK . Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story . Immunology Letters . 85 . 2 . 197–203 . January 2003 . 12527228 . 10.1016/S0165-2478(02)00231-6 .
• Awomoyi AA . The human solute carrier family 11 member 1 protein (SLC11A1): linking infections, autoimmunity and cancer? . FEMS Immunology and Medical Microbiology . 49 . 3 . 324–9 . April 2007 . 17378896 . 1890654 . 10.1111/j.1574-695X.2007.00231.x .
• Liu J, Fujiwara TM, Buu NT, Sánchez FO, Cellier M, Paradis AJ, Frappier D, Skamene E, Gros P, Morgan K . Identification of polymorphisms and sequence variants in the human homologue of the mouse natural resistance-associated macrophage protein gene . American Journal of Human Genetics . 56 . 4 . 845–53 . April 1995 . 7717395 . 1801220 .
• Vidal SM, Malo D, Vogan K, Skamene E, Gros P . Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg . Cell . 73 . 3 . 469–85 . May 1993 . 8490962 . 10.1016/0092-8674(93)90135-D . 54294811 .
• Blackwell JM, Barton CH, White JK, Searle S, Baker AM, Williams H, Shaw MA . Genomic organization and sequence of the human NRAMP gene: identification and mapping of a promoter region polymorphism . Molecular Medicine . 1 . 2 . 194–205 . January 1995 . 8529098 . 2229945 . 10.1007/BF03401567.
• Kishi F, Nobumoto M . Identification of natural resistance-associated macrophage protein in peripheral blood lymphocytes . Immunology Letters . 47 . 1–2 . 93–6 . 1996 . 8537108 . 10.1016/0165-2478(95)00070-L .
• Gruenheid S, Pinner E, Desjardins M, Gros P . Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome . The Journal of Experimental Medicine . 185 . 4 . 717–30 . February 1997 . 9034150 . 2196151 . 10.1084/jem.185.4.717 .
• Atkinson PG, Blackwell JM, Barton CH . Nramp1 locus encodes a 65 kDa interferon-gamma-inducible protein in murine macrophages . The Biochemical Journal . 325 (Pt 3) . 3. 779–86 . August 1997 . 9271100 . 1218623 . 10.1042/bj3250779. 325 .
• Gruenheid S, Canonne-Hergaux F, Gauthier S, Hackam DJ, Grinstein S, Gros P . The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes . The Journal of Experimental Medicine . 189 . 5 . 831–41 . March 1999 . 10049947 . 2192949 . 10.1084/jem.189.5.831 .
• Searle S, Blackwell JM . Evidence for a functional repeat polymorphism in the promoter of the human NRAMP1 gene that correlates with autoimmune versus infectious disease susceptibility . Journal of Medical Genetics . 36 . 4 . 295–9 . April 1999 . 10227396 . 1734346 . 10.1136/jmg.36.4.295 .
• Marquet S, Lepage P, Hudson TJ, Musser JM, Schurr E . Complete nucleotide sequence and genomic structure of the human NRAMP1 gene region on chromosome region 2q35 . Mammalian Genome . 11 . 9 . 755–62 . September 2000 . 10967134 . 10.1007/s003350010151 . 11308779 .
• Canonne-Hergaux F, Calafat J, Richer E, Cellier M, Grinstein S, Borregaard N, Gros P . Expression and subcellular localization of NRAMP1 in human neutrophil granules . Blood . 100 . 1 . 268–75 . July 2002 . 12070036 . 10.1182/blood.V100.1.268 . free .
• Rodríguez MR, González-Escribano MF, Aguilar F, Valenzuela A, García A, Núñez-Roldán A . Association of NRAMP1 promoter gene polymorphism with the susceptibility and radiological severity of rheumatoid arthritis . Tissue Antigens . 59 . 4 . 311–5 . April 2002 . 12135431 . 10.1034/j.1399-0039.2002.590410.x . free .
• Bassuny WM, Ihara K, Matsuura N, Ahmed S, Kohno H, Kuromaru R, Miyako K, Hara T . Association study of the NRAMP1 gene promoter polymorphism and early-onset type 1 diabetes . Immunogenetics . 54 . 4 . 282–5 . July 2002 . 12136340 . 10.1007/s00251-002-0459-3 . 19801943 .
• Søborg C, Andersen AB, Madsen HO, Kok-Jensen A, Skinhøj P, Garred P . Natural resistance-associated macrophage protein 1 polymorphisms are associated with microscopy-positive tuberculosis . The Journal of Infectious Diseases . 186 . 4 . 517–21 . August 2002 . 12195379 . 10.1086/341775 . free .
• Puzyrev VP, Freĭdin MB, Rudko AA, Strelis AK, Kolokolova OV . [Polymorphisms of the candidate genes for genetic susceptibility to tuberculosis in the Slavic population of Siberia: a pilot study] . Molekuliarnaia Biologiia . 36 . 5 . 788–91 . 2002 . 12391841 .

Notes and References

1. Cellier M, Govoni G, Vidal S, Kwan T, Groulx N, Liu J, Sanchez F, Skamene E, Schurr E, Gros P . Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression . The Journal of Experimental Medicine . 180 . 5 . 1741–52 . November 1994 . 7964458 . 2191750 . 10.1084/jem.180.5.1741 .
2. Kishi F . Isolation and characterization of human Nramp cDNA . Biochemical and Biophysical Research Communications . 204 . 3 . 1074–80 . November 1994 . 7980580 . 10.1006/bbrc.1994.2572 .
3. Web site: Entrez Gene: SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1.
4. ((Teras IuKh)), Ryĭgas EM, ((Kazakova II)), ((Ranne KhP)), Trapido LE . [Detection of Trichomonas in the bronchi, sputum and oral cavity in various lung diseases] . Terapevticheskii Arkhiv . 52 . 3 . 123–5 . 1980 . 7385031 .