SLAMF6 explained

SLAM family member 6 is a protein that in humans is encoded by the SLAMF6 gene.^{[1] [2]}

The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.^[3]

Further reading

• Claus M, Meinke S, Bhat R, Watzl C . Regulation of NK cell activity by 2B4, NTB-A and CRACC. . Front. Biosci. . 13 . 13. 956–65 . 2007 . 17981603 . 10.2741/2735 . free .
• Hercend T, Meuer S, Brennan A, etal . Natural killer-like function of activated T lymphocytes: differential blocking effects of monoclonal antibodies specific for a 90-kDa clonotypic structure . Cell. Immunol. . 86 . 2 . 381–92 . 1984 . 6610481 . 10.1016/0008-8749(84)90393-9 .
• Kong G, Dalton M, Wardenburg JB, etal . Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function . Mol. Cell. Biol. . 16 . 9 . 5026–35 . 1996 . 8756661 . 10.1128/MCB.16.9.5026. 231504 .
• Lee YJ, Luisiri P, Clark MR . A novel complex, p40/42, is constitutively associated with the B cell antigen receptor and phosphorylated upon receptor stimulation . J. Immunol. . 157 . 9 . 3828–37 . 1996 . 10.4049/jimmunol.157.9.3828 . 8892612 .
• Gray CW, Ward RV, Karran E, etal . Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response . Eur. J. Biochem. . 267 . 18 . 5699–710 . 2000 . 10971580 . 10.1046/j.1432-1327.2000.01589.x . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Del Valle JM, Engel P, Martín M . The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2) . J. Biol. Chem. . 278 . 19 . 17430–7 . 2003 . 12621057 . 10.1074/jbc.M301569200 . free .
• Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC . Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation . J. Immunol. . 171 . 5 . 2485–95 . 2003 . 12928397 . 10.4049/jimmunol.171.5.2485. free .
• Clark HF, Gurney AL, Abaya E, etal . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 .
• Valdez PA, Wang H, Seshasayee D, etal . NTB-A, a new activating receptor in T cells that regulates autoimmune disease . J. Biol. Chem. . 279 . 18 . 18662–9 . 2004 . 14988414 . 10.1074/jbc.M312313200 . free .
• Flaig RM, Stark S, Watzl C . Cutting edge: NTB-A activates NK cells via homophilic interaction . J. Immunol. . 172 . 11 . 6524–7 . 2004 . 15153464 . 10.4049/jimmunol.172.11.6524. 38642218 .
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites . Protein Sci. . 13 . 10 . 2819–24 . 2005 . 15340161 . 10.1110/ps.04682504 . 2286551 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Stark S, Watzl C . 2B4 (CD244), NTB-A and CRACC (CS1) stimulate cytotoxicity but no proliferation in human NK cells . Int. Immunol. . 18 . 2 . 241–7 . 2006 . 16410313 . 10.1093/intimm/dxh358 . free .
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1 . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .
• Eissmann P, Watzl C . Molecular analysis of NTB-A signaling: a role for EAT-2 in NTB-A-mediated activation of human NK cells . J. Immunol. . 177 . 5 . 3170–7 . 2006 . 16920955 . 10.4049/jimmunol.177.5.3170. free .
• Cao E, Ramagopal UA, Fedorov A, etal . NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family . Immunity . 25 . 4 . 559–70 . 2006 . 17045824 . 10.1016/j.immuni.2006.06.020 . free .
• Banerjee P, Feuer G, Barker E . Human T-cell leukemia virus type 1 (HTLV-1) p12I down-modulates ICAM-1 and -2 and reduces adherence of natural killer cells, thereby protecting HTLV-1-infected primary CD4+ T cells from autologous natural killer cell-mediated cytotoxicity despite the reduction of major histocompatibility complex class I molecules on infected cells . J. Virol. . 81 . 18 . 9707–17 . 2007 . 17609265 . 10.1128/JVI.00887-07 . 2045425 .

Notes and References

1. Bottino C, Falco M, Parolini S, Marcenaro E, Augugliaro R, Sivori S, Landi E, Biassoni R, Notarangelo LD, Moretta L, Moretta A . NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease . J Exp Med . 194 . 3 . 235–46 . Aug 2001 . 11489943 . 2193462 . 10.1084/jem.194.3.235 .
2. Web site: Entrez Gene: SLAMF6 SLAM family member 6.
3. Web site: Entrez Gene: SLAMF6 SLAM family member 6.