CD84 explained

CD84 (Cluster of Differentiation 84) is a human protein encoded by the gene.^[1]

Function

Members of the CD2 (see MIM 186990) subgroup of the Ig superfamily, such as CD84, have similar patterns of conserved disulfide bonds and function in adhesion interactions between T lymphocytes and accessory cells.

Interactions

CD84 has been shown to interact with SH2D1A.^{[2] [3] [4] [5]}

See also

• Cluster of differentiation

Further reading

• Andreesen R, Bross KJ, Osterholz J, Emmrich F . Human macrophage maturation and heterogeneity: analysis with a newly generated set of monoclonal antibodies to differentiation antigens . Blood . 67 . 5 . 1257–64 . May 1986 . 3008886 . 10.1182/blood.V67.5.1257.1257. free .
• Kingsmore SF, Souryal CA, Watson ML, Patel DD, Seldin MF . Physical and genetic linkage of the genes encoding Ly-9 and CD48 on mouse and human chromosomes 1 . Immunogenetics . 42 . 1 . 59–62 . 1995 . 7797269 . 10.1007/BF00164988 . 28529549 .
• de la Fuente MA, Pizcueta P, Nadal M, Bosch J, Engel P . CD84 leukocyte antigen is a new member of the Ig superfamily . Blood . 90 . 6 . 2398–405 . Sep 1997 . 9310491 . 10.1182/blood.V90.6.2398. free .
• Krause SW, Rehli M, Heinz S, Ebner R, Andreesen R . Characterization of MAX.3 antigen, a glycoprotein expressed on mature macrophages, dendritic cells and blood platelets: identity with CD84 . The Biochemical Journal . 346 Pt 3 . 3 . 729–36 . Mar 2000 . 10698700 . 1220906 . 10.1042/0264-6021:3460729 .
• Palou E, Pirotto F, Solé J, Freed JH, Peral B, Vilardell C, Vilella R, Vives J, Gayá A . Genomic characterization of CD84 reveals the existence of five isoforms differing in their cytoplasmic domains . Tissue Antigens . 55 . 2 . 118–27 . Feb 2000 . 10746783 . 10.1034/j.1399-0039.2000.550203.x .
• Lucas AD, Chadwick N, Warren BF, Jewell DP, Gordon S, Powrie F, Greaves DR . The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo . The American Journal of Pathology . 158 . 3 . 855–66 . Mar 2001 . 11238035 . 1850344 . 10.1016/S0002-9440(10)64034-5 .
• Shlapatska LM, Mikhalap SV, Berdova AG, Zelensky OM, Yun TJ, Nichols KE, Clark EA, Sidorenko SP . CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A . Journal of Immunology . 166 . 9 . 5480–7 . May 2001 . 11313386 . 10.4049/jimmunol.166.9.5480 . free .
• Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C . Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP . Blood . 97 . 12 . 3867–74 . Jun 2001 . 11389028 . 10.1182/blood.V97.12.3867 . 10530544 . free .
• Lewis J, Eiben LJ, Nelson DL, Cohen JI, Nichols KE, Ochs HD, Notarangelo LD, Duckett CS . Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family . Clinical Immunology . 100 . 1 . 15–23 . Jul 2001 . 11414741 . 10.1006/clim.2001.5035 .
• Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C . Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients . The Journal of Biological Chemistry . 276 . 39 . 36809–16 . Sep 2001 . 11477068 . 10.1074/jbc.M101305200 . 39889619 . free .
• Martin M, Romero X, de la Fuente MA, Tovar V, Zapater N, Esplugues E, Pizcueta P, Bosch J, Engel P . CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1 . Journal of Immunology . 167 . 7 . 3668–76 . Oct 2001 . 11564780 . 10.4049/jimmunol.167.7.3668 . free .
• Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C . Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells . The EMBO Journal . 20 . 21 . 5840–52 . Nov 2001 . 11689425 . 125701 . 10.1093/emboj/20.21.5840 .
• Tangye SG, van de Weerdt BC, Avery DT, Hodgkin PD . CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2 . European Journal of Immunology . 32 . 6 . 1640–9 . Jun 2002 . 12115647 . 10.1002/1521-4141(200206)32:6<1640::AID-IMMU1640>3.0.CO;2-S . free .
• Del Valle JM, Engel P, Martín M . The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2) . The Journal of Biological Chemistry . 278 . 19 . 17430–7 . May 2003 . 12621057 . 10.1074/jbc.M301569200 . free .
• Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC . Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation . Journal of Immunology . 171 . 5 . 2485–95 . Sep 2003 . 12928397 . 10.4049/jimmunol.171.5.2485 . free .
• Zaiss M, Hirtreiter C, Rehli M, Rehm A, Kunz-Schughart LA, Andreesen R, Hennemann B . CD84 expression on human hematopoietic progenitor cells . Experimental Hematology . 31 . 9 . 798–805 . Sep 2003 . 12962726 . 10.1016/S0301-472X(03)00187-5 . free .
• Romero X, Benítez D, March S, Vilella R, Miralpeix M, Engel P . Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4) . Tissue Antigens . 64 . 2 . 132–44 . Aug 2004 . 15245368 . 10.1111/j.1399-0039.2004.00247.x .
• Nanda N, Andre P, Bao M, Clauser K, Deguzman F, Howie D, Conley PB, Terhorst C, Phillips DR . Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling . Blood . 106 . 9 . 3028–34 . Nov 2005 . 16037392 . 10.1182/blood-2005-01-0333 . free .

Notes and References

1. Web site: Entrez Gene: CD84 CD84 molecule.
2. Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC . Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation . Journal of Immunology . 171 . 5 . 2485–95 . Sep 2003 . 12928397 . 10.4049/jimmunol.171.5.2485 . free .
3. Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C . Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP . Blood . 97 . 12 . 3867–74 . Jun 2001 . 11389028 . 10.1182/blood.V97.12.3867 . 10530544 . free .
4. Tangye SG, van de Weerdt BC, Avery DT, Hodgkin PD . CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2 . European Journal of Immunology . 32 . 6 . 1640–9 . Jun 2002 . 12115647 . 10.1002/1521-4141(200206)32:6<1640::AID-IMMU1640>3.0.CO;2-S . free .
5. Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C . Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients . The Journal of Biological Chemistry . 276 . 39 . 36809–16 . Sep 2001 . 11477068 . 10.1074/jbc.M101305200 . 39889619 . free .