SL-164 explained

Iupac Name:5-chloro-3-(4-chloro-2-methylphenyl)-2-methylquinazolin-4-one
Width:200
Cas Number:3476-88-8
Unii:KQ54T3QL7X
Atc Prefix:none
Pubchem:63386
Chemspiderid:57049
C:16
H:12
Cl:2
N:2
O:1
Smiles:ClC1=CC(C)=C(N2C(C)=NC3=CC=CC(Cl)=C3C2=O)C=C1
Stdinchi:1S/C16H12Cl2N2O/c1-9-8-11(17)6-7-14(9)20-10(2)19-13-5-3-4-12(18)15(13)16(20)21/h3-8H,1-2H3
Stdinchikey:KUIHLOHNUGOCTO-UHFFFAOYSA-N

SL-164, also known as dicloqualone or DCQ, is an analogue of methaqualone developed in the late 1960s by a team at Sumitomo.[1] SL-164 has similar sedative, hypnotic[2] and properties to the parent compound, but was never marketed for clinical use, due to higher risk of convulsions. Like other 4-substituted analogues, like methylmethaqualone, SL-164 may cause seizures.[3]

Notes and References

  1. US . 3651230 . Compositions And Methods For Tranquilizing With Substituted 3-Phenyl-4-Quinazolinone Derivatives .
  2. Saito C, Sakai S, Yukawa Y, Yamamoto H, Takagi H . Pharmacological studies on 2-methyl-3(2'-methyl-4'-chlorophenyl)-5-chloro-4[H)-quinazolinone (SL-164) | journal = Arzneimittel-Forschung | volume = 19 | issue = 12 | pages = 1945–9 | date = December 1969 | pmid = 4985336 ].
  3. Boltze KH, Dell HD, Lehwald H, Lorenz D, Rueberg-Schweer M . [Substituted 4-Quinazolinone Derivatives As Hypnotics] . German . Arzneimittel-Forschung . 13 . 688–701 . August 1963 . 14085923 .