SKIP explained

SKIP is an acronym for Skeletal muscle and kidney enriched inositol phosphatase, which is a human gene.^[1]

Function

This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternative splicing of this gene results in two transcript variants encoding different isoforms.^[2] Overexpression of SKIP in mice affects osmoregulation in kidney collecting ducts.^[3]

Further reading

• Drayer AL, Pesesse X, De Smedt F, Communi D, Moreau C, Erneux C . The family of inositol and phosphatidylinositol polyphosphate 5-phosphatases . Biochemical Society Transactions . 24 . 4 . 1001–5 . Nov 1996 . 8968500 . 10.1042/bst0241001.
• Mitchell CA, Brown S, Campbell JK, Munday AD, Speed CJ . Regulation of second messengers by the inositol polyphosphate 5-phosphatases . Biochemical Society Transactions . 24 . 4 . 994–1000 . Nov 1996 . 8968499 . 10.1042/bst0240994.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Chen J, Xu J, Zhao W, Hu G, Cheng H, Kang Y, Xie Y, Lu Y . Characterization of human LNX, a novel ligand of Numb protein X that is downregulated in human gliomas . The International Journal of Biochemistry & Cell Biology . 37 . 11 . 2273–83 . Nov 2005 . 16002321 . 10.1016/j.biocel.2005.02.028 .
• Cardoso C, Leventer RJ, Ward HL, Toyo-Oka K, Chung J, Gross A, Martin CL, Allanson J, Pilz DT, Olney AH, Mutchinick OM, Hirotsune S, Wynshaw-Boris A, Dobyns WB, Ledbetter DH . Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3 . American Journal of Human Genetics . 72 . 4 . 918–30 . Apr 2003 . 12621583 . 1180354 . 10.1086/374320 .
• Ijuin T, Takenawa T . SKIP negatively regulates insulin-induced GLUT4 translocation and membrane ruffle formation . Molecular and Cellular Biology . 23 . 4 . 1209–20 . Feb 2003 . 12556481 . 141139 . 10.1128/MCB.23.4.1209-1220.2003 .
• Gurung R, Tan A, Ooms LM, McGrath MJ, Huysmans RD, Munday AD, Prescott M, Whisstock JC, Mitchell CA . Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation . The Journal of Biological Chemistry . 278 . 13 . 11376–85 . Mar 2003 . 12536145 . 10.1074/jbc.M209991200 . free .
• Ijuin T, Mochizuki Y, Fukami K, Funaki M, Asano T, Takenawa T . Identification and characterization of a novel inositol polyphosphate 5-phosphatase . The Journal of Biological Chemistry . 275 . 15 . 10870–5 . Apr 2000 . 10753883 . 10.1074/jbc.275.15.10870 . free .

Notes and References

1. Web site: Entrez Gene: SKIP skeletal muscle and kidney enriched inositol phosphatase.
2. Web site: Entrez Gene: SKIP skeletal muscle and kidney enriched inositol phosphatase.
3. Pernot E, Terryn S, Cheong SC, Markadieu N, Janas S, Blockmans M, Jacoby M, Pouillon V, Gayral S, Rossier BC, Beauwens R, Erneux C, Devuyst O, Schurmans S . The inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting system . Pflügers Archiv . 462 . 6 . 871–83 . Dec 2011 . 21938401 . 10.1007/s00424-011-1028-0 . 27923688 .