SKF-77,434 explained

SKF-77,434 is a drug which acts as a selective dopamine D1 receptor partial agonist, and has stimulant and anorectic effects. Unlike other D1 agonists with higher efficacy such as SKF-81,297 and 6-Br-APB, SKF-77,434 does not maintain self-administration in animal studies, and so has been researched as a potential treatment for cocaine addiction.[1] [2] [3] [4] [5] [6] [7]

Notes and References

  1. Grech DM, Spealman RD, Bergman J . Self-administration of D1 receptor agonists by squirrel monkeys . Psychopharmacology . 125 . 2 . 97–104 . May 1996 . 8783382 . 10.1007/BF02249407 . 36378721 .
  2. Weed MR, Paul IA, Dwoskin LP, Moore SE, Woolverton WL . The relationship between reinforcing effects and in vitro effects of D1 agonists in monkeys . The Journal of Pharmacology and Experimental Therapeutics . 283 . 1 . 29–38 . October 1997 . 9336305 .
  3. Platt DM, Rowlett JK, Spealman RD . Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434 . The Journal of Pharmacology and Experimental Therapeutics . 293 . 3 . 1017–26 . June 2000 . 10869406 .
  4. Platt DM, Rowlett JK, Spealman RD . Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeys . Psychopharmacology . 157 . 2 . 208–16 . September 2001 . 11594448 . 10.1007/s002130100779 . 6567384 .
  5. Mutschler NH, Bergman J . Effects of chronic administration of the D1 receptor partial agonist SKF 77434 on cocaine self-administration in rhesus monkeys . Psychopharmacology . 160 . 4 . 362–70 . April 2002 . 11919663 . 10.1007/s00213-001-0976-z . 20483120 .
  6. Desai RI, Terry P, Katz JL . A comparison of the locomotor stimulant effects of D1-like receptor agonists in mice . Pharmacology, Biochemistry, and Behavior . 81 . 4 . 843–8 . August 2005 . 16000217 . 10.1016/j.pbb.2005.06.006 . 2525256 .
  7. Katz JL, Kopajtic TA, Terry P . Effects of dopamine D1-like receptor agonists on food-maintained operant behavior in rats . Behavioural Pharmacology . 17 . 4 . 303–9 . June 2006 . 16914948 . 10.1097/01.fbp.0000205015.67079.f7 . 24288989 .

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