SKF-38,393 explained

SKF-38393 is a synthetic compound of the benzazepine chemical class which acts as a selective D₁/D₅ receptor partial agonist.^[1] It has stimulant and anorectic effects.^{[2] [3]}

The trimethylation of SKF-38,393 leads to a named agent called Trepipam.

As with fenoldopam the inclusion of a chlorine halogen gave an agent that is called SKF-81,297.

Notes and References

1. Dubois A, Savasta M, Curet O, Scatton B . Autoradiographic distribution of the D1 agonist [3H]SKF 38393, in the rat brain and spinal cord. Comparison with the distribution of D2 dopamine receptors . Neuroscience . 19 . 1 . 125–37 . September 1986 . 2946980 . 10.1016/0306-4522(86)90010-2. 19520384 .
2. Trampus M, Ferri N, Adami M, Ongini E . The dopamine D1 receptor agonists, A68930 and SKF 38393, induce arousal and suppress REM sleep in the rat . European Journal of Pharmacology . 235 . 1 . 83–7 . April 1993 . 8100197 . 10.1016/0014-2999(93)90823-Z.
3. Cooper SJ, Francis J, Rusk IN . The anorectic effect of SK&F 38393, a selective dopamine D1 receptor agonist: a microstructural analysis of feeding and related behaviour . Psychopharmacology . 100 . 2 . 182–7 . 1990 . 1968277 . 10.1007/BF02244403. 23977403 .