SIX5 explained

Homeobox protein SIX5 is a protein that in humans is encoded by the SIX5 gene.^{[1] [2]}

Further reading

• Murakami Y, Ohto H, Ikeda U, Shimada K, Momoi T, Kawakami K . Promoter of mDMAHP/Six5: differential utilization of multiple transcription initiation sites and positive/negative regulatory elements . Hum. Mol. Genet. . 7 . 13 . 2103–12 . 1999 . 9817928 . 10.1093/hmg/7.13.2103 . free .
• Winchester CL, Ferrier RK, Sermoni A, Clark BJ, Johnson KJ . Characterization of the expression of DMPK and SIX5 in the human eye and implications for pathogenesis in myotonic dystrophy . Hum. Mol. Genet. . 8 . 3 . 481–92 . 1999 . 9949207 . 10.1093/hmg/8.3.481 . free .
• Ohto H, Kamada S, Tago K, Tominaga SI, Ozaki H, Sato S, Kawakami K . Cooperation of Six and Eya in Activation of Their Target Genes through Nuclear Translocation of Eya . Mol. Cell. Biol. . 19 . 10 . 6815–24 . 2000 . 10490620 . 84678 . 10.1128/mcb.19.10.6815.
• Harris SE, Winchester CL, Johnson KJ . Functional analysis of the homeodomain protein SIX5 . Nucleic Acids Res. . 28 . 9 . 1871–8 . 2000 . 10756185 . 103302 . 10.1093/nar/28.9.1871 .
• Winchester C, Robertson S, MacLeod T, Johnson K, Thomas M . Expression of a homeobox gene (SIX5) in borderline ovarian tumours . J. Clin. Pathol. . 53 . 3 . 212–7 . 2000 . 10823141 . 1731149 . 10.1136/jcp.53.3.212 .
• Dintilhac A, Bernués J . HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences . J. Biol. Chem. . 277 . 9 . 7021–8 . 2002 . 11748221 . 10.1074/jbc.M108417200 . free . 10261/112516 . free .
• Sato S, Nakamura M, Cho DH, Tapscott SJ, Ozaki H, Kawakami K . Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1 . Hum. Mol. Genet. . 11 . 9 . 1045–58 . 2002 . 11978764 . 10.1093/hmg/11.9.1045 . free .
• Fougerousse F, Durand M, Lopez S, Suel L, Demignon J, Thornton C, Ozaki H, Kawakami K, Barbet P, Beckmann JS, Maire P . Six and Eya expression during human somitogenesis and MyoD gene family activation . J. Muscle Res. Cell. Motil. . 23 . 3 . 255–64 . 2003 . 12500905 . 10.1023/A:1020990825644 . 42497614 .
• Huda Zoghbi . Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .
• Hoskins BE, Cramer CH, Silvius D, Zou D, Raymond RM, Orten DJ, Kimberling WJ, Smith RJ, Weil D, Petit C, Otto EA, Xu PX, Hildebrandt F . Transcription Factor SIX5 Is Mutated in Patients with Branchio-Oto-Renal Syndrome . Am. J. Hum. Genet. . 80 . 4 . 800–4 . 2007 . 17357085 . 1852719 . 10.1086/513322 .

Notes and References

1. Boucher CA, King SK, Carey N, Krahe R, Winchester CL, Rahman S, Creavin T, Meghji P, Bailey ME, Chartier FL . A novel homeodomain-encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable (CTG)n repeat . Hum Mol Genet . 4 . 10 . 1919–25 . Apr 1996 . 8595416 . 10.1093/hmg/4.10.1919 .
2. Web site: Entrez Gene: SIX5 sine oculis homeobox homolog 5 (Drosophila).