SIRPB1 explained

Signal-regulatory protein beta-1 is a protein that in humans is encoded by the SIRPB1 gene.^{[1] [2]} SIRPB1 has also recently been designated CD172B (cluster of differentiation 172B).

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Alternatively spliced transcript variants have been found for this gene.^[3]

Interactions

SIRPB1 has been shown to interact with TYROBP.^{[4] [5]}

Further reading

• Dietrich J, Cella M, Seiffert M, etal . Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells. . J. Immunol. . 164 . 1 . 9–12 . 2000 . 10604985 . 10.4049/jimmunol.164.1.9. free .
• Tomasello E, Cant C, Bühring HJ, etal . Association of signal-regulatory proteins beta with KARAP/DAP-12. . Eur. J. Immunol. . 30 . 8 . 2147–56 . 2000 . 10940905 . 10.1002/1521-4141(2000)30:8<2147::AID-IMMU2147>3.0.CO;2-1 . 84258013 .
• Deloukas P, Matthews LH, Ashurst J, etal . The DNA sequence and comparative analysis of human chromosome 20. . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . free .
• Cannon JP . Haire RN . Litman GW . Identification of diversified genes that contain immunoglobulin-like variable regions in a protochordate. . Nat. Immunol. . 3 . 12 . 1200–7 . 2002 . 12415263 . 10.1038/ni849 . 19367972 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Suzuki Y, Yamashita R, Shirota M, etal . Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions . Genome Res. . 14 . 9 . 1711–8 . 2004 . 15342556 . 10.1101/gr.2435604 . 515316 .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Liu Y, Soto I, Tong Q, etal . SIRPbeta1 is expressed as a disulfide-linked homodimer in leukocytes and positively regulates neutrophil transepithelial migration . J. Biol. Chem. . 280 . 43 . 36132–40 . 2006 . 16081415 . 10.1074/jbc.M506419200 . free .
• Liu T, Qian WJ, Gritsenko MA, etal . Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry . J. Proteome Res. . 4 . 6 . 2070–80 . 2006 . 16335952 . 10.1021/pr0502065 . 1850943 .
• Laplana M, Royo JL, Aluja A, López R, Heine-Sunyer H, Fibla J . SIRPB1 copy-number polymorphism as candidate quantitative trait locus for impulsive-disinhibited personality . Genes, Brain and Behavior . 13 . 7 . 653–62 . September 2014 . 25039969 . 10.1111/gbb.12154 . free . 10486/667487 . free .

Notes and References

1. Kharitonenkov A . Chen Z . Sures I . Wang H . Schilling J . Ullrich A . A family of proteins that inhibit signalling through tyrosine kinase receptors . Nature . 386 . 6621 . 181–6 . April 1997 . 9062191 . 10.1038/386181a0 . 1997Natur.386..181K . 4259314 .
2. van den Berg TK . van Beek EM . Buhring HJ . Colonna M . Hamaguchi M . Howard CJ . Kasuga M . Liu Y . Matozaki T . Neel BG . Parkos CA . Sano S . Vignery A . Vivier E . Wright M . Zawatzky R . Barclay AN . A nomenclature for signal regulatory protein family members . J Immunol . 175 . 12 . 7788–9 . December 2005 . 16339511 . 10.4049/jimmunol.175.12.7788. 41479985 .
3. Web site: Entrez Gene: SIRPB1 signal-regulatory protein beta 1.
4. Dietrich . J . Cella M . Seiffert M . Bühring H J . Colonna M . January 2000 . Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells . J. Immunol. . 164 . 1 . 9–12 . UNITED STATES. 0022-1767. 10604985 . 10.4049/jimmunol.164.1.9. free .
5. Tomasello . E . Cant C . Bühring H J . Vély F . André P . Seiffert M . Ullrich A . Vivier E . August 2000 . Association of signal-regulatory proteins beta with KARAP/DAP-12 . Eur. J. Immunol. . 30 . 8 . 2147–56 . GERMANY. 0014-2980. 10940905 . 10.1002/1521-4141(2000)30:8<2147::AID-IMMU2147>3.0.CO;2-1 . 84258013 .