SIN3B explained

Paired amphipathic helix protein Sin3b is a protein that in humans is encoded by the SIN3B gene.^{[1] [2]}

Interactions

SIN3B has been shown to interact with HDAC1,^{[3] [4]} Zinc finger and BTB domain-containing protein 16,^[5] SUDS3^[6] and IKZF1.^{[4] [7]}

See also

• Transcription coregulator

Further reading

• Ayer DE, Lawrence QA, Eisenman RN . Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3 . Cell . 80 . 5 . 767–76 . Mar 1995 . 7889570 . 10.1016/0092-8674(95)90355-0 . 8749951 . free .
• David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A . Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein . Oncogene . 16 . 19 . 2549–56 . May 1998 . 9627120 . 10.1038/sj.onc.1202043 . 655636 .
• Koipally J, Renold A, Kim J, Georgopoulos K . Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes . The EMBO Journal . 18 . 11 . 3090–100 . Jun 1999 . 10357820 . 1171390 . 10.1093/emboj/18.11.3090 .
• Naruse Y, Aoki T, Kojima T, Mori N . Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes . Proceedings of the National Academy of Sciences of the United States of America . 96 . 24 . 13691–6 . Nov 1999 . 10570134 . 24126 . 10.1073/pnas.96.24.13691 . 1999PNAS...9613691N . free .
• Spronk CA, Tessari M, Kaan AM, Jansen JF, Vermeulen M, Stunnenberg HG, Vuister GW . The Mad1-Sin3B interaction involves a novel helical fold . Nature Structural Biology . 7 . 12 . 1100–4 . Dec 2000 . 11101889 . 10.1038/81944 . 12451972 .
• Spronk CA, Jansen JF, Tessari M, Kaan AM, Aelen J, Lasonder E, Stunnenberg HG, Vuister GW . Sequence-specific assignment of the PAH2 domain of Sin3B free and bound to Mad1 . Journal of Biomolecular NMR . 19 . 4 . 377–8 . Apr 2001 . 11370785 . 10.1023/A:1011262214741 . 31789681 . 2066/79476 . free .
• Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA . Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex . Molecular and Cellular Biology . 22 . 8 . 2743–50 . Apr 2002 . 11909966 . 133736 . 10.1128/MCB.22.8.2743-2750.2002 .
• Rayman JB, Takahashi Y, Indjeian VB, Dannenberg JH, Catchpole S, Watson RJ, te Riele H, Dynlacht BD . E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex . Genes & Development . 16 . 8 . 933–47 . Apr 2002 . 11959842 . 152357 . 10.1101/gad.969202 .
• Koipally J, Georgopoulos K . A molecular dissection of the repression circuitry of Ikaros . The Journal of Biological Chemistry . 277 . 31 . 27697–705 . Aug 2002 . 12015313 . 10.1074/jbc.M201694200 . free .
• Yang L, Mei Q, Zielinska-Kwiatkowska A, Matsui Y, Blackburn ML, Benedetti D, Krumm AA, Taborsky GJ, Chansky HA . An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B . The Biochemical Journal . 369 . Pt 3 . 651–7 . Feb 2003 . 12398767 . 1223118 . 10.1042/BJ20020854 .
• Petrie K, Guidez F, Howell L, Healy L, Waxman S, Greaves M, Zelent A . The histone deacetylase 9 gene encodes multiple protein isoforms . The Journal of Biological Chemistry . 278 . 18 . 16059–72 . May 2003 . 12590135 . 10.1074/jbc.M212935200 . free .
• Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W . Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1 . Genes & Development . 17 . 7 . 896–911 . Apr 2003 . 12670868 . 196026 . 10.1101/gad.252103 .
• Dugast-Darzacq C, Pirity M, Blanck JK, Scherl A, Schreiber-Agus N . Mxi1-SRalpha: a novel Mxi1 isoform with enhanced transcriptional repression potential . Oncogene . 23 . 55 . 8887–99 . Nov 2004 . 15467743 . 10.1038/sj.onc.1208107 . 30045920 .
• Rampalli S, Pavithra L, Bhatt A, Kundu TK, Chattopadhyay S . Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex . Molecular and Cellular Biology . 25 . 19 . 8415–29 . Oct 2005 . 16166625 . 1265755 . 10.1128/MCB.25.19.8415-8429.2005 .
• Xu Y, Sengupta PK, Seto E, Smith BD . Regulatory factor for X-box family proteins differentially interact with histone deacetylases to repress collagen alpha2(I) gene (COL1A2) expression . The Journal of Biological Chemistry . 281 . 14 . 9260–70 . Apr 2006 . 16464847 . 1434794 . 10.1074/jbc.M511724200 . free .

Notes and References

1. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Research . 5 . 3 . 169–76 . Jun 1998 . 9734811 . 10.1093/dnares/5.3.169 . free .
2. Web site: Entrez Gene: SIN3B SIN3 homolog B, transcription regulator (yeast).
3. Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D . Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation . Genes & Development . 13 . 15 . 1924–35 . Aug 1999 . 10444591 . 316920 . 10.1101/gad.13.15.1924 .
4. Koipally J, Renold A, Kim J, Georgopoulos K . Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes . The EMBO Journal . 18 . 11 . 3090–100 . Jun 1999 . 10357820 . 1171390 . 10.1093/emboj/18.11.3090 .
5. David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A . Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein . Oncogene . 16 . 19 . 2549–56 . May 1998 . 9627120 . 10.1038/sj.onc.1202043 . 655636 .
6. Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA . Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex . Molecular and Cellular Biology . 22 . 8 . 2743–50 . Apr 2002 . 11909966 . 133736 . 10.1128/MCB.22.8.2743-2750.2002 .
7. Koipally J, Georgopoulos K . A molecular dissection of the repression circuitry of Ikaros . The Journal of Biological Chemistry . 277 . 31 . 27697–705 . Aug 2002 . 12015313 . 10.1074/jbc.M201694200 . free .