SNF1LK2 explained

Serine/threonine-protein kinase SIK2 is an enzyme that in humans is encoded by the SIK2 gene.^{[1] [2]}

Interactions

SNF1LK2 has been shown to interact with CRTC2.^[3]

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones . DNA Research . 9 . 3 . 99–106 . Jun 2002 . 12168954 . 10.1093/dnares/9.3.99 . 10.1.1.500.923 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . Sep 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Research . 5 . 5 . 277–86 . Oct 1998 . 9872452 . 10.1093/dnares/5.5.277 . free .
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Research . 11 . 3 . 422–35 . Mar 2001 . 11230166 . 311072 . 10.1101/gr.GR1547R .
• Horike N, Takemori H, Katoh Y, Doi J, Min L, Asano T, Sun XJ, Yamamoto H, Kasayama S, Muraoka M, Nonaka Y, Okamoto M . Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2 . The Journal of Biological Chemistry . 278 . 20 . 18440–7 . May 2003 . 12624099 . 10.1074/jbc.M211770200 . free .
• Katoh M, Katoh M . Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats . International Journal of Oncology . 23 . 5 . 1471–6 . Nov 2003 . 14532992 . 10.3892/ijo.23.5.1471 .
• Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR . LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1 . The EMBO Journal . 23 . 4 . 833–43 . Feb 2004 . 14976552 . 381014 . 10.1038/sj.emboj.7600110 .
• Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M . The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector . Cell . 119 . 1 . 61–74 . Oct 2004 . 15454081 . 10.1016/j.cell.2004.09.015 . 18616459 . free .
• Katoh Y, Takemori H, Min L, Muraoka M, Doi J, Horike N, Okamoto M . Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm . European Journal of Biochemistry . 271 . 21 . 4307–19 . Nov 2004 . 15511237 . 10.1111/j.1432-1033.2004.04372.x . free .

Notes and References

1. Katoh M, Katoh M . Identification and characterization of human FOXN5 and rat Foxn5 genes in silico . International Journal of Oncology . 24 . 5 . 1339–44 . May 2004 . 15067358 . 10.3892/ijo.24.5.1339 .
2. Web site: Entrez Gene: SNF1LK2 SNF1-like kinase 2.
3. Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M . The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector . Cell . 119 . 1 . 61–74 . Oct 2004 . 15454081 . 10.1016/j.cell.2004.09.015 . 18616459 . free .