SIGLEC9 explained

Sialic acid-binding Ig-like lectin 9 is a protein that in humans is encoded by the SIGLEC9 gene.^{[1] [2]}

Further reading

• Yousef GM, Luo LY, Diamandis EP . Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4 . Anticancer Res. . 19 . 4B . 2843–52 . 2000 . 10652563 .
• Angata T, Varki A . Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways . J. Biol. Chem. . 275 . 29 . 22127–35 . 2000 . 10801860 . 10.1074/jbc.M002775200 . free .
• Zhang JQ, Nicoll G, Jones C, Crocker PR . Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes . J. Biol. Chem. . 275 . 29 . 22121–6 . 2000 . 10801862 . 10.1074/jbc.M002788200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Clark HF, Gurney AL, Abaya E, etal . The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 .
• Sonnenburg JL, Altheide TK, Varki A . A uniquely human consequence of domain-specific functional adaptation in a sialic acid-binding receptor . Glycobiology . 14 . 4 . 339–46 . 2004 . 14693915 . 10.1093/glycob/cwh039 . free .
• Grimwood J, Gordon LA, Olsen A, etal . The DNA sequence and biology of human chromosome 19 . Nature . 428 . 6982 . 529–35 . 2004 . 15057824 . 10.1038/nature02399 . 2004Natur.428..529G . free .
• Ikehara Y, Ikehara SK, Paulson JC . Negative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9 . J. Biol. Chem. . 279 . 41 . 43117–25 . 2004 . 15292262 . 10.1074/jbc.M403538200 . free .
• Avril T, Floyd H, Lopez F, etal . The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells . J. Immunol. . 173 . 11 . 6841–9 . 2005 . 15557178 . 10.4049/jimmunol.173.11.6841. free .
• von Gunten S, Yousefi S, Seitz M, etal . Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment . Blood . 106 . 4 . 1423–31 . 2005 . 15827126 . 10.1182/blood-2004-10-4112 . free .
• Rapoport EM, Pazynina GV, Sablina MA, etal . Probing sialic acid binding Ig-like lectins (siglecs) with sulfated oligosaccharides . Biochemistry Mosc. . 71 . 5 . 496–504 . 2006 . 16732727 . 10.1134/S0006297906050051 . 11537303 .
• Biedermann B, Gil D, Bowen DT, Crocker PR . Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors . Leuk. Res. . 31 . 2 . 211–20 . 2007 . 16828866 . 10.1016/j.leukres.2006.05.026 .

Notes and References

1. Foussias G, Yousef GM, Diamandis EP . Identification and molecular characterization of a novel member of the siglec family (SIGLEC9) . Genomics . 67 . 2 . 171–8 . Aug 2000 . 10903842 . 10.1006/geno.2000.6208 .
2. Web site: Entrez Gene: SIGLEC9 sialic acid binding Ig-like lectin 9.