SIGLEC7 explained

Sialic acid-binding Ig-like lectin 7 is a protein that in humans is encoded by the SIGLEC7 gene.^{[1] [2]} SIGLEC7 has also been designated as CD328 (cluster of differentiation 328).

Further reading

• Reif K, Buday L, Downward J, Cantrell DA . SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases. . J. Biol. Chem. . 269 . 19 . 14081–7 . 1994 . 10.1016/S0021-9258(17)36757-1 . 8188688 . free .
• Falco M, Biassoni R, Bottino C, etal . Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells. . J. Exp. Med. . 190 . 6 . 793–802 . 1999 . 10499918 . 10.1084/jem.190.6.793 . 2195632 .
• Ye X, Mehlen P, Rabizadeh S, etal . TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. . J. Biol. Chem. . 274 . 42 . 30202–8 . 1999 . 10514511 . 10.1074/jbc.274.42.30202 . free .
• Vitale C, Romagnani C, Falco M, etal . Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells. . Proc. Natl. Acad. Sci. U.S.A. . 96 . 26 . 15091–6 . 2000 . 10611343 . 10.1073/pnas.96.26.15091 . 24778 . free .
• Angata T, Varki A . Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily. . Glycobiology . 10 . 4 . 431–8 . 2000 . 10764831 . 10.1093/glycob/10.4.431 . free .
• Ito A, Handa K, Withers DA, etal . Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression. . FEBS Lett. . 498 . 1 . 116–20 . 2001 . 11389909 . 10.1016/S0014-5793(01)02476-0 . 6755832 . free .
• Book: Mingari MC, Vitale C, Romagnani C, etal . Progress in Basic and Clinical Immunology . Regulation of myeloid cell proliferation and survival by p75/AIRM1 and CD33 surface receptors . 495 . 55–61 . 11774609 . 10.1007/978-1-4615-0685-0_8. Advances in Experimental Medicine and Biology . 2001 . 978-1-4613-5194-8 .
• Yousef GM, Ordon MH, Foussias G, Diamandis EP . Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes. . Gene . 286 . 2 . 259–70 . 2002 . 11943481 . 10.1016/S0378-1119(02)00432-8 .
• Alphey MS, Attrill H, Crocker PR, van Aalten DM . High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family. . J. Biol. Chem. . 278 . 5 . 3372–7 . 2003 . 12438315 . 10.1074/jbc.M210602200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Nicoll G, Avril T, Lock K, etal . Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms. . Eur. J. Immunol. . 33 . 6 . 1642–8 . 2003 . 12778482 . 10.1002/eji.200323693 . 7541832 . free .
• Dimasi N, Moretta A, Moretta L, etal . Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1. . Acta Crystallogr. D . 60 . Pt 2 . 401–3 . 2004 . 14747738 . 10.1107/S0907444903028439 .
• Ikehara Y, Ikehara SK, Paulson JC . Negative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9. . J. Biol. Chem. . 279 . 41 . 43117–25 . 2004 . 15292262 . 10.1074/jbc.M403538200 . free .
• Avril T, Floyd H, Lopez F, etal . The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells. . J. Immunol. . 173 . 11 . 6841–9 . 2005 . 15557178 . 10.4049/jimmunol.173.11.6841. free .
• Yamaji T, Mitsuki M, Teranishi T, Hashimoto Y . Characterization of inhibitory signaling motifs of the natural killer cell receptor Siglec-7: attenuated recruitment of phosphatases by the receptor is attributed to two amino acids in the motifs. . Glycobiology . 15 . 7 . 667–76 . 2005 . 15703304 . 10.1093/glycob/cwi048 . free .
• Attrill H, Takazawa H, Witt S, etal . The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design. . Biochem. J. . 397 . 2 . 271–8 . 2006 . 16623661 . 10.1042/BJ20060103 . 1513286 .
• Rapoport EM, Pazynina GV, Sablina MA, etal . Probing sialic acid binding Ig-like lectins (siglecs) with sulfated oligosaccharides. . Biochemistry Mosc. . 71 . 5 . 496–504 . 2006 . 16732727 . 10.1134/S0006297906050051 . 11537303 .
• Biedermann B, Gil D, Bowen DT, Crocker PR . Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors. . Leuk. Res. . 31 . 2 . 211–20 . 2007 . 16828866 . 10.1016/j.leukres.2006.05.026 .

Notes and References

1. Nicoll G, Ni J, Liu D, Klenerman P, Munday J, Dubock S, Mattei MG, Crocker PR . Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes . J Biol Chem . 274 . 48 . 34089–95 . Dec 1999 . 10567377 . 10.1074/jbc.274.48.34089 . free .
2. Web site: Entrez Gene: SIGLEC7 sialic acid binding Ig-like lectin 7.